Document Detail

Telomerase activity in human chorionic villi and placenta determined by TRAP and in situ TRAP assay.
MedLine Citation:
PMID:  9859865     Owner:  NLM     Status:  MEDLINE    
Telomerase activity (TA) was analysed in human chorionic villi and placenta in normal and abnormal pregnancy using the telomeric repeat amplification protocol (TRAP) and in situ TRAP assay. Twenty chorionic villi specimens and 25 placenta specimens from normal pregnancies were examined as well as placenta specimens from 10 cases of intrauterine growth retardation (IUGR; nine asymmetric and one symmetric). TA was detected in 18 of the 20 (90 per cent) chorionic villi specimens and in 18 of the 25 (72 per cent) placenta specimens from normal pregnancy. However, no or only weak TA was exhibited in the placenta specimens of the nine asymmetric IUGR cases. In situ TRAP assay detected TA in trophoblastic cells from normal pregnancy, but not in trophoblastic cells from cases of asymmetric IUGR.
T Izutsu; T Kudo; T Sato; I Nishiya; K Ohyashiki; M Mori; K Nakagawara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  19     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-03-03     Completed Date:  1999-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  613-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan.
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MeSH Terms
Chorionic Villi / enzymology*
DNA Primers / chemistry
Fetal Growth Retardation / enzymology*
Hela Cells
In Situ Hybridization, Fluorescence
Placenta / enzymology
Polymerase Chain Reaction / methods
Pregnancy / metabolism*
Repetitive Sequences, Nucleic Acid / genetics
Telomerase / metabolism*
Telomere / genetics
Reg. No./Substance:
0/DNA Primers; EC

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