| Telomerase activity in human chorionic villi and placenta determined by TRAP and in situ TRAP assay. | |
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MedLine Citation:
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PMID: 9859865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomerase activity (TA) was analysed in human chorionic villi and placenta in normal and abnormal pregnancy using the telomeric repeat amplification protocol (TRAP) and in situ TRAP assay. Twenty chorionic villi specimens and 25 placenta specimens from normal pregnancies were examined as well as placenta specimens from 10 cases of intrauterine growth retardation (IUGR; nine asymmetric and one symmetric). TA was detected in 18 of the 20 (90 per cent) chorionic villi specimens and in 18 of the 25 (72 per cent) placenta specimens from normal pregnancy. However, no or only weak TA was exhibited in the placenta specimens of the nine asymmetric IUGR cases. In situ TRAP assay detected TA in trophoblastic cells from normal pregnancy, but not in trophoblastic cells from cases of asymmetric IUGR. |
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Authors:
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T Izutsu; T Kudo; T Sato; I Nishiya; K Ohyashiki; M Mori; K Nakagawara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Placenta Volume: 19 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-03-03 Completed Date: 1999-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 613-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Villi / enzymology* DNA Primers / chemistry Female Fetal Growth Retardation / enzymology* Hela Cells Humans In Situ Hybridization, Fluorescence Placenta / enzymology Polymerase Chain Reaction / methods Pregnancy / metabolism* Repetitive Sequences, Nucleic Acid / genetics Telomerase / metabolism* Telomere / genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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