| Telomerase activity in hematopoietic cells is associated with self-renewal potential. | |
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MedLine Citation:
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PMID: 8808676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been proposed that the biological clock underlying the limited division potential of eukaryotic cells is telomere length. We assayed telomerase activity in single cells of the hematopoietic and immune systems. We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. The frequency of telomerase-expressing cells within each population was proportional to the frequency of cells thought to have self-renewal potential. Among bone marrow hematopoietic stem cells, 70% exhibited detectable telomerase activity. The telomerase-expressing somatic cells observed in this study are not thought to be immortal, and expression was not correlated with cell cycle distribution or differentiation state. This study demonstrates that the developmental characteristic most consistently associated with telomerase expression is self-renewal potential. |
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Authors:
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S J Morrison; K R Prowse; P Ho; I L Weissman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunity Volume: 5 ISSN: 1074-7613 ISO Abbreviation: Immunity Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 207-16 Citation Subset: IM |
Affiliation:
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Department of Pathology, Stanford University School of Medicine, California 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Hematopoietic Stem Cells / enzymology*, physiology Humans Mice Mice, Inbred C57BL Telomerase / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA42551/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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