| Telomerase RNA levels limit the telomere length equilibrium. | |
| | |
MedLine Citation:
|
PMID: 17381301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Small functional RNAs play essential roles in many biological processes. Regulating the level of these small RNAs can be as important as maintaining their function in cells. The telomerase RNA is maintained in cells at a steady-state level where small changes in concentration can have a profound impact on function. Cells that have half the level of the telomerase RNA cannot maintain telomeres through many cell divisions. People who are heterozygous for telomerase RNA mutations have the diseases dyskeratosis congenita and aplastic anemia, caused by short telomeres that result in loss of tissue renewal capacity. Mice heterozygous for telomerase RNA show haploinsufficiency in telomere length maintenance and also show loss of tissue renewal capacity. It is remarkable that small changes in the level of this functional RNA can have such profound effects in cells. This tight regulation highlights the importance of controlling the action of telomerase in cells. |
| | |
Authors:
|
C W Greider |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Cold Spring Harbor symposia on quantitative biology Volume: 71 ISSN: 0091-7451 ISO Abbreviation: Cold Spring Harb. Symp. Quant. Biol. Publication Date: 2006 |
Date Detail:
|
Created Date: 2007-03-26 Completed Date: 2007-06-21 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 1256107 Medline TA: Cold Spring Harb Symp Quant Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
|
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia, Aplastic
/
enzymology,
genetics Animals Cell Division Dyskeratosis Congenita / enzymology, genetics Female Heterozygote Humans Male Mice Mice, Knockout RNA / genetics, metabolism* Telomerase / deficiency, genetics, metabolism* Telomere / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
R01AG027406/AG/NIA NIH HHS; R01AG39383/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/telomerase RNA; 63231-63-0/RNA; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: RNA as a flexible scaffold for proteins: yeast telomerase and beyond.
Next Document: Sensing metabolic signals with nascent RNA transcripts: the T box and S box riboswitches as paradigm...