| Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum. | |
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MedLine Citation:
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PMID: 22763879 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Conventionally, cells described in the stroma of the intestinal wall are fibroblasts/fibrocytes, mast cells, plasma cells, eosinophils, macrophages and, interstitial cells of Cajal (ICCs), the latter being considered as the pacemakers of gastrointestinal rhythmicity. Recently, a new type of stromal cell called telocyte (TCs) was found in various cavitary and non-cavitary organs (www.telocytes.com). We show here direct electron microscopical evidence for the presence of TCs in the lamina propria of rat jejunum just beneath the epithelial layer of the mucosal crypts and in between the smooth muscle cells (SMCs) of muscularis mucosae. TCs are characterized by: several very long (tens to hundreds of µm) prolongations called telopodes (Tps). Tps (with caliber below the resolving power of light microscopy) display podomeres (thin segments ≤0.2 µm) and podoms (dilations accommodating caveolae, mitochondria, and endoplasmic reticulum). Tps present dichotomous branching and form a three dimensional network close to immune cells, SMCs or nerve bundles. TCs could play a role in intercellular signaling and control of local tissue homeostasis. |
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Authors:
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D Cretoiu; S M Cretoiu; A A Simionescu; L M Popescu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histology and histopathology Volume: 27 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 1067-78 Citation Subset: IM |
Affiliation:
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Department of Cellular and Molecular Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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