| Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats. | |
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MedLine Citation:
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PMID: 19424279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II receptor blockers have beneficial effects in patients with cardiac diseases. We examined the effects of an angiotensin II receptor blocker, telmisartan, on cardiac remodeling in renovascular hypertensive rats. Telmisartan was administered to renovascular hypertensive rats at either a high dose (5 mg per kg per day; high-T group) or a low dose (0.5 mg per kg per day; low-T group). After 4 weeks, histomorphological studies, including an evaluation of cardiac fibrosis, hypertrophy, vascular changes and measurement of the serum aldosterone concentration, were performed. A significant reduction in systolic blood pressure was obtained in the high-T group, and the heart weight to body weight ratio in the high-T and low-T groups was significantly lower than that in the control renovascular hypertensive group. Cardiac and perivascular fibrosis and the accumulation of collagen were significantly suppressed in the high-T and low-T groups. An increase in the cross-sectional area of the myocytes and vessel hypertrophy were significantly prevented in the high-T group, but not in the low-T group. The dependence of myocyte lengthening on the blood pressure was also prevented in the high-T group, but not to a significant degree. The elevation of the serum aldosterone level observed in the renovascular hypertensive group was prevented in both the high-T and low-T groups.Treatment with telmisartan strongly suppresses the progression of cardiac fibrosis, rather than cardiac hypertrophy, in a manner that is independent of the blood pressure. |
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Authors:
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Makoto Kawai; Kenichi Hongo; Kimiaki Komukai; Satoshi Morimoto; Makoto Nagai; Shingo Seki; Ikuo Taniguchi; Seibu Mochizuki; Michihiro Yoshimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-08 |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 32 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-06 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
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Languages: eng Pagination: 604-10 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. cadmk@jikei.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood Angiotensin II Type 1 Receptor Blockers / therapeutic use* Animals Benzimidazoles / therapeutic use* Benzoates / therapeutic use* Blood Vessels / pathology Cardiomegaly / drug therapy*, pathology Cell Size Coronary Vessels / pathology Fibrosis Heart Diseases / drug therapy*, pathology Hemodynamics / drug effects, physiology Hypertension, Renovascular / drug therapy*, pathology Male Myocardium / metabolism, pathology Myocytes, Cardiac / pathology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Benzimidazoles; 0/Benzoates; 144701-48-4/telmisartan; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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