| Telmisartan improves endothelial function in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 18049303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND:: Hypertension is a cardiovascular risk factor commonly associated with endothelial dysfunction and increased renal vascular resistance. Angiotensin receptor blockers (ARBs) may beneficially affect these parameters via antagonism of angiotensin type 1 (AT1) receptor-mediated vasoconstriction and vascular superoxide production. We therefore investigated whether the new ARB telmisartan improves endothelial function and renal vascular resistance in patients with essential hypertension. METHODS:: Thirty-seven patients with essential hypertension were randomized to receive telmisartan, the calcium channel blocker nisoldipine, or their combination for 6 weeks in a prospective, parallel group study. Brachial artery flow-mediated (endothelium-dependent) dilation (FMD) and renal vascular resistance index (RVRI) were evaluated using high-resolution ultrasound before, at 3 weeks (low dose), and at 6 weeks (high dose) after initiation of treatment. RESULTS:: At baseline, FMD and RVRI did not significantly differ between treatment groups. After 3 weeks of treatment neither treatment significantly changed FMD or RVRI. After 6 weeks of treatment, patients randomized to receive telmisartan alone or the combination, but not those treated with nisoldipine alone, displayed a significantly improved FMD, whereas RVRI values again were not significantly different as compared to those at baseline. CONCLUSION:: In our study cohort of patients with essential hypertension, treatment with telmisartan improved FMD but did not change RVRI. Future studies will demonstrate whether this telmisartan-induced effect may contribute to a blood pressure-independent reduction in cardiovascular morbidity. |
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Authors:
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Ralf A Benndorf; Daniel Appel; Renke Maas; Edzard Schwedhelm; Ulrich O Wenzel; Rainer H Böger |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 50 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-11-30 Completed Date: 2008-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 367-71 Citation Subset: IM |
Affiliation:
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Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center, Hamburg-Eppendorf, Germany. benndorf@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin II Type 1 Receptor Blockers / pharmacology, therapeutic use Antihypertensive Agents / pharmacology, therapeutic use Benzimidazoles / pharmacology, therapeutic use* Benzoates / pharmacology, therapeutic use* Blood Pressure / drug effects Drug Therapy, Combination Endothelium, Vascular / drug effects*, physiopathology Female Humans Hypertension / drug therapy* Kidney / blood supply, drug effects Male Middle Aged Nisoldipine / pharmacology, therapeutic use Prospective Studies Single-Blind Method Treatment Outcome Vascular Resistance / drug effects Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Benzoates; 144701-48-4/telmisartan; 63675-72-9/Nisoldipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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