| Telmisartan Lowers Home Blood Pressure and Improves Insulin Resistance Without Correlation Between Their Changes. | |
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MedLine Citation:
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PMID: 21269058 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Telmisartan is an angiotensin type 1 receptor blocker (ARB), which also partially activates liganding peroxisome proliferator-activated receptor gamma. However, the relationship between the effects of telmisartan on hemodynamics and metabolism has not sufficiently been elucidated in clinical settings. We examined the long-term effects of telmisartan on hemodynamics including home blood pressure (BP) and on insulin resistance representing as homeostasis model assessment (HOMA-R). Twenty-seven hypertensive patients were consecutively enrolled at our outpatient department. At entry, all of the participants were previously prescribed another ARB for more than 3 months and then the former ARB were replaced by telmisartan. Hemodynamic and metabolic parameters were measured before treatment and at points 1 and 3 months after treatment with telmisartan. Telmisartan significantly lowered home systolic blood pressure (SBP) and diastolic blood pressure (DBP) (DBP) and improved HOMA-R during the treatment period. However, the changes in home SBP and DBP were not correlated with that of HOMA-R. In conclusion, telmisartan lowers home BP and improves insulin resistance without correlation between their changes. |
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Authors:
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Kazuhiro Kobayashi; Yoichi Ohno; Tsuneo Takenaka; Naofumi Ikeda; Hirokazu Okada; Yoshihiko Kanno; Hiromichi Suzuki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-26 |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: - ISSN: 1525-6006 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nephrology, Saitama Medical University, Saitama, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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