| Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice. | |
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MedLine Citation:
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PMID: 21427223 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Diet-induced obesity is reported to induce a phenotypic switch in adipose tissue macrophages from an antiinflammatory M2 state to a proinflammatory M1 state. Telmisartan, an angiotensin II type 1 receptor blocker and a peroxisome proliferator-activated receptor-γ agonist, reportedly has more beneficial effects on insulin sensitivity than other angiotensin II type 1 receptor blockers. In this study, we studied the effects of telmisartan on the adipose tissue macrophage phenotype in high-fat-fed mice. Telmisartan was administered for 5 wk to high-fat-fed C57BL/6 mice. Insulin sensitivity, macrophage infiltration, and the gene expressions of M1 and M2 markers in visceral adipose tissues were then examined. An insulin- or a glucose-tolerance test showed that telmisartan treatment improved insulin resistance, decreasing the body weight gain, visceral fat weight, and adipocyte size without affecting the amount of energy intake. Telmisartan reduced the mRNA expression of CD11c and TNF-α, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209, and macrophage galactose N-acetyl-galactosamine specific lectin (Mgl2), in a quantitative RT-PCR analysis. A flow cytometry analysis showed that telmisartan decreased the number of M1 macrophages in visceral adipose tissues. In conclusion, telmisartan improves insulin sensitivity and modulates adipose tissue macrophage polarization to an antiinflammatory M2 state in high-fat-fed mice. |
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Authors:
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Shiho Fujisaka; Isao Usui; Yukiko Kanatani; Masashi Ikutani; Ichiro Takasaki; Koichi Tsuneyama; Yoshiaki Tabuchi; Agussalim Bukhari; Yu Yamazaki; Hikari Suzuki; Satoko Senda; Aminuddin Aminuddin; Yoshinori Nagai; Kiyoshi Takatsu; Masashi Kobayashi; Kazuyuki Tobe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
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Title: Endocrinology Volume: - ISSN: 1945-7170 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The First Department of Internal Medicine (S.F., I.U., Y.K., A.B., Y.Y., H.S., S.S., A.A., K.To.), Department of Immunobiology and Pharmacological Genetics (M.I., Y.N., K.Ta.), Graduate School of Medicine and Pharmaceutical Science for Research, Division of Molecular Genetics Research (I.T., Y.T.), Life Science Research Center, Department of Diagnostic Pathology (K.Ts.), University Hospital (M.K.), University of Toyama, 930-0194 Toyama, Japan. |
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