| Telithromycin for the treatment of acute bacterial maxillary sinusitis: a review of a new antibacterial agent. | |
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MedLine Citation:
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PMID: 16217977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Telithromycin, the first approved ketolide antibiotic, was developed to treat community-acquired respiratory tract infections, including acute bacterial maxillary sinusitis (ABMS). A previously published study showed that a 5-day course of 800 mg telithromycin once daily is as effective as a 10-day course in the treatment of ABMS. MATERIALS AND METHODS: Data were pooled from two controlled, multinational, prospective, randomized, double-blinded ABMS trials comparing 5-day telithromycin (800 mg once daily) with 10-day amoxicillin-clavulanate (500/125 mg 3 times daily) and cefuroxime axetil (250 mg twice daily). Clinical cure and bacteriologic eradication rates were compared by means of descriptive statistics. RESULTS: The clinical cure rate for telithromycin was 80.9% versus 77.4% for comparators; bacteriologic eradication rate for telithromycin was 84.9% versus 81.7% for comparators. Most adverse events were mild to moderate in intensity and, most commonly, gastrointestinal in nature. CONCLUSIONS: These results support the conclusion that 5 days of treatment with telithromycin is as safe and effective in patients with ABMS as a 10-day course of treatment with amoxicillin-clavulanate or cefuroxime axetil. |
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Authors:
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Guy Tellier; Stephen A Brunton; Roomi Nusrat |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Southern medical journal Volume: 98 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-12 Completed Date: 2005-10-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 863-8 Citation Subset: AIM; IM |
Affiliation:
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Zoom International Clinical Research Group, St. Jerome, Quebec, Canada. gtellier@zoominternational.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Amoxicillin-Potassium Clavulanate Combination / therapeutic use Anti-Bacterial Agents / therapeutic use* Cefuroxime / analogs & derivatives, therapeutic use Double-Blind Method Drug Administration Schedule Female Haemophilus influenzae / isolation & purification Humans Ketolides / therapeutic use* Male Maxillary Sinusitis / drug therapy*, microbiology Middle Aged Moraxella (Branhamella) catarrhalis / isolation & purification Prospective Studies Randomized Controlled Trials as Topic Staphylococcus aureus / isolation & purification Streptococcus pneumoniae / isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Ketolides; 0/telithromycin; 55268-75-2/Cefuroxime; 64544-07-6/cefuroxime axetil; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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