| Telemetry in a motion-sickness model implicates the abdominal vagus in motion-induced gastric dysrhythmia. | |
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MedLine Citation:
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PMID: 20360423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In humans, motion sickness is associated with disruption of normal gastric myoelectric activity, and it has been proposed that this results from an imbalance of autonomic nervous system activity. We used the established Suncus murinus (house musk shrew) model of motion-induced emesis to investigate the effect of horizontal motion on gastric myoelectric activity (recorded using telemetry) and the involvement of the abdominal vagi. Surgical vagotomy increased baseline dysrhythmia and reduced the dominant power of the gastric myoelectric signals. In response to motion, normal gastric myoelectric activity was reduced in sham-operated animals but not in vagotomized animals. Vagotomy, however, failed to affect motion-induced emesis. In conclusion, motion had a differential effect in sham-operated and vagotomized animals, which is consistent with the hypothesis that motion-induced dysrhythmia arises from an autonomic nervous system imbalance. |
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Authors:
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Nathalie Percie du Sert; Kit M Chu; Man K Wai; John A Rudd; Paul L R Andrews |
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Publication Detail:
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Type: Journal Article Date: 2010-04-01 |
Journal Detail:
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Title: Experimental physiology Volume: 95 ISSN: 1469-445X ISO Abbreviation: Exp. Physiol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
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Languages: eng Pagination: 768-73 Citation Subset: IM |
Affiliation:
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University of London, UK. npercied@sgul.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System / physiology Male Membrane Potentials / physiology Motion Sickness / physiopathology* Shrews Stomach / physiology Telemetry Vagus Nerve / physiology* Vomiting / etiology |
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