Document Detail


Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis.
MedLine Citation:
PMID:  9931112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Radio-telemetry systems offer the ability to measure blood pressure and heart rate in experimental models of hypertension without the stress artifacts induced by some other methods. We therefore aimed to develop improved, nonparametric regression methods for radio-telemetry data and to use these to assess the effects of pharmacological interventions on cardiac and vascular hypertrophy in the stroke-prone spontaneously hypertensive rat. One control group and 5 groups treated either with losartan (alone or in combination with NG-nitro-L-arginine methyl ester [ L-NAME]), perindopril (also alone or in combination with L-NAME), or hydralazine plus hydrochlorothiazide were monitored for 4 weeks. Cardiac hypertrophy was assessed by the left ventricle plus septum weight to body weight ratio and vascular hypertrophy by flow-cytometry analysis of vascular smooth muscle cell polyploidy. Hemodynamic series were split into trend and cyclic components by the seasonal and trend decomposition procedure based on Loess and compared between groups by Loess regression modeling. Systolic and diastolic blood pressures were reduced systematically by losartan and perindopril (P<10(-10)) but to a lesser extent by hydralazine plus hydrochlorothiazide (P<10(-8)), and diurnal variation was reduced in the latter group (P<10(-6)). L-NAME significantly reduced the hypotensive effect only of losartan. Vascular and cardiac hypertrophy were significantly attenuated with losartan or perindopril, but were unchanged with other treatments. The new analysis proposed here identifies differential effects on trends and cyclic variation and associations with regression of end-organ damage for losartan and perindopril compared with hydralazine plus hydrochlorothiazide. The method offers a powerful tool for detailed investigation of radio-telemetry data.
Authors:
N H Anderson; A M Devlin; D Graham; J J Morton; C A Hamilton; J L Reid; N J Schork; A F Dominiczak
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  33     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-26     Completed Date:  1999-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  248-55     Citation Subset:  IM    
Affiliation:
Department of Medicine and Therapeutics, University of Glasgow, Scotland, UK. niall@stats.gla.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology*
Aorta / drug effects,  metabolism
Blood Pressure / drug effects*
Cardiomegaly / pathology,  physiopathology*,  prevention & control
Cell Nucleus / drug effects,  metabolism
DNA / analysis
Diastole / drug effects
Female
Heart Rate / drug effects*
Humans
Hydralazine / pharmacology
Hydrochlorothiazide / pharmacology
Hypertension / genetics*,  prevention & control
Indoles / pharmacology
Losartan / pharmacology
Lymphocytes / metabolism
Male
Muscle, Smooth, Vascular / drug effects,  metabolism
NG-Nitroarginine Methyl Ester / pharmacology
Perindopril
Rats
Rats, Inbred SHR
Systole / drug effects
Telemetry / methods*
Time Factors
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Indoles; 114798-26-4/Losartan; 50903-99-6/NG-Nitroarginine Methyl Ester; 58-93-5/Hydrochlorothiazide; 82834-16-0/Perindopril; 86-54-4/Hydralazine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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