| Teicoplanin therapy in children: a review. | |
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MedLine Citation:
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PMID: 2151065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Teicoplanin has been investigated mainly in adults and to a lesser extent in children. Pharmacological studies in children aged 2-12 years showed that a daily dose of 3-6 mg/kg of teicoplanin was insufficient to maintain microbiologically effective trough serum levels, while a regimen of 10 mg/kg/day was sufficient to obtain effective serum concentrations. Teicoplanin has been administered, alone or in combination therapy, to neutropenic or non-neutropenic paediatric patients. Combinations of teicoplanin (10 mg/kg/day) plus beta-lactams or aminoglycosides have been found effective in the treatment of febrile episodes in neutropenic (less than 500 pmn/microliters) children. Teicoplanin, 3-10 mg/kg i.v., has been administered as the sole antibiotic agent as a daily dose to more than 100 children and newborns with documented or suspected Gram-positive infections. Overall, teicoplanin was found to be a very effective and well tolerated treatment for Gram-positive infections in pediatric patients. Further trials are required to confirm these observations. |
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Authors:
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D Bassetti; M Cruciani |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Scandinavian journal of infectious diseases. Supplementum Volume: 72 ISSN: 0300-8878 ISO Abbreviation: Scand J Infect Dis Suppl Publication Date: 1990 |
Date Detail:
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Created Date: 1991-06-05 Completed Date: 1991-06-05 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0251025 Medline TA: Scand J Infect Dis Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 35-7 Citation Subset: IM |
Affiliation:
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Institute of Infectious Diseases, University of Verona, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Infections
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drug therapy* Child Glycopeptides / pharmacokinetics, therapeutic use Humans Neutropenia / complications* Teicoplanin |
| Chemical | |
Reg. No./Substance:
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0/Glycopeptides; 61036-62-2/Teicoplanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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