| Teicoplanin reduces in-vitro reactivity and murine lethality of Salmonella minnesota R595 lipopolysaccharide. | |
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MedLine Citation:
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PMID: 1535068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three different tests were performed to investigate the effect of teicoplanin on lipopolysaccharide (LPS). After incubation for 3 h with teicoplanin, LPS from Salmonella minnesota R595 showed reduced reactivity in the metachromatic dimethyl-methylene blue assay and the limulus amoebocyte lysate test. In addition, galactosamine-sensitized mice had an increased survival rate, from 29% to 72%, when teicoplanin was pre-incubated for 3 h with the LPS to be injected intraperitoneally. The results suggest that teicoplanin may have a neutralizing effect on LPS. |
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Authors:
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A Focà; G Matera; M C Berlinghieri; M C Liberto; G B De Sarro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 29 ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-07-23 Completed Date: 1992-07-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 443-6 Citation Subset: IM |
Affiliation:
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Institute of Microbiology, University of Reggio Calabria, Policlinico Mater Domini, Catanzaro, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacology* Galactosamine / pharmacology Glycopeptides / pharmacology Limulus Test Lipopolysaccharides / toxicity* Male Methylene Blue / analogs & derivatives Mice Mice, Inbred C57BL Polymyxin B / pharmacology Salmonella / drug effects* Teicoplanin |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Glycopeptides; 0/Lipopolysaccharides; 1404-26-8/Polymyxin B; 23481-50-7/1,9-dimethylmethylene blue; 61-73-4/Methylene Blue; 61036-62-2/Teicoplanin; 7535-00-4/Galactosamine |
| Comments/Corrections | |
Comment In:
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J Antimicrob Chemother. 1994 Jan;33(1):181
[PMID:
8157561
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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