Document Detail

Teicoplanin reduces in-vitro reactivity and murine lethality of Salmonella minnesota R595 lipopolysaccharide.
MedLine Citation:
PMID:  1535068     Owner:  NLM     Status:  MEDLINE    
Three different tests were performed to investigate the effect of teicoplanin on lipopolysaccharide (LPS). After incubation for 3 h with teicoplanin, LPS from Salmonella minnesota R595 showed reduced reactivity in the metachromatic dimethyl-methylene blue assay and the limulus amoebocyte lysate test. In addition, galactosamine-sensitized mice had an increased survival rate, from 29% to 72%, when teicoplanin was pre-incubated for 3 h with the LPS to be injected intraperitoneally. The results suggest that teicoplanin may have a neutralizing effect on LPS.
A Focà; G Matera; M C Berlinghieri; M C Liberto; G B De Sarro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  29     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-23     Completed Date:  1992-07-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Institute of Microbiology, University of Reggio Calabria, Policlinico Mater Domini, Catanzaro, Italy.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Galactosamine / pharmacology
Glycopeptides / pharmacology
Limulus Test
Lipopolysaccharides / toxicity*
Methylene Blue / analogs & derivatives
Mice, Inbred C57BL
Polymyxin B / pharmacology
Salmonella / drug effects*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Glycopeptides; 0/Lipopolysaccharides; 1404-26-8/Polymyxin B; 23481-50-7/1,9-dimethylmethylene blue; 61-73-4/Methylene Blue; 61036-62-2/Teicoplanin; 7535-00-4/Galactosamine
Comment In:
J Antimicrob Chemother. 1994 Jan;33(1):181   [PMID:  8157561 ]

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