Document Detail

Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus.
MedLine Citation:
PMID:  20944066     Owner:  NLM     Status:  MEDLINE    
The cell wall of Staphylococcus aureus is characterized by an extremely high degree of cross-linking within its peptidoglycan (PGN). Penicillin-binding protein 4 (PBP4) is required for the synthesis of this highly cross-linked peptidoglycan. We found that wall teichoic acids, glycopolymers attached to the peptidoglycan and important for virulence in Gram-positive bacteria, act as temporal and spatial regulators of PGN metabolism, controlling the level of cross-linking by regulating PBP4 localization. PBP4 normally localizes at the division septum, but in the absence of wall teichoic acids synthesis, it becomes dispersed throughout the entire cell membrane and is unable to function normally. As a consequence, the peptidoglycan of TagO null mutants, impaired in wall teichoic acid biosynthesis, has a decreased degree of cross-linking, which renders it more susceptible to the action of lysozyme, an enzyme produced by different host organisms as an initial defense against bacterial infection.
Magda L Atilano; Pedro M Pereira; James Yates; Patricia Reed; Helena Veiga; Mariana G Pinho; Sérgio R Filipe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-13
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  107     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-11-30     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18991-6     Citation Subset:  IM    
Laboratory of Bacterial Cell Surfaces and Pathogenesis and Laboratory of Bacterial Cell Biology, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2781-901 Oeiras, Portugal.
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MeSH Terms
Cell Membrane / genetics,  metabolism*
Penicillin-Binding Proteins / genetics,  metabolism*
Peptidoglycan / genetics,  metabolism*
Staphylococcus aureus / genetics,  metabolism*,  pathogenicity
Teichoic Acids / genetics,  metabolism*
Reg. No./Substance:
0/Penicillin-Binding Proteins; 0/Peptidoglycan; 0/Teichoic Acids

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