Document Detail

The Tei index identifies a differential effect on left and right ventricular function with low-dose anthracycline chemotherapy.
MedLine Citation:
PMID:  16455426     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to study the relative effect on left ventricular (LV) and right ventricular (RV) function of low-dose anthracycline-containing chemotherapy regimes. METHODS: A total of 23 patients (mean age 48 +/- 20 years) underwent echocardiographic examinations before any anthracycline had been administered and then after low-dose anthracycline (doxorubicin 50-125 mg/m2). The Tei index was used to compare the relative effects on RV and LV function. RESULTS: Anthracycline administration was significantly associated with an increase in the LV Tei index (0.38 +/- 0.12 vs 0.46 +/- 0.16, P = .02). There was no significant change in the RV Tei index (0.19 +/- 0.10 vs 0.20 +/- 0.10, P = .72). Comparing the relative effect on global LV and RV function the change in LV Tei was significantly greater than the change in RV Tei (0.07 +/- 0.13 vs 0.01 +/- 0.09, P = .044). CONCLUSIONS: Low-dose anthracycline administration has a significant negative impact on LV function but does not affect RV function.
Mark Belham; Anton Kruger; Colin Pritchard
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  19     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-04-26     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-10     Citation Subset:  IM    
Department of Cardiology, Royal Cornwall Hospital, Cornwall, United Kingdom.
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MeSH Terms
Aged, 80 and over
Anthracyclines / adverse effects*
Antineoplastic Agents / adverse effects
Dose-Response Relationship, Drug
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Severity of Illness Index*
Stroke Volume
Ventricular Dysfunction, Left / chemically induced*,  ultrasonography*
Ventricular Dysfunction, Right / chemically induced*,  ultrasonography*
Reg. No./Substance:
0/Anthracyclines; 0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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