| The Tei index identifies a differential effect on left and right ventricular function with low-dose anthracycline chemotherapy. | |
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MedLine Citation:
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PMID: 16455426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to study the relative effect on left ventricular (LV) and right ventricular (RV) function of low-dose anthracycline-containing chemotherapy regimes. METHODS: A total of 23 patients (mean age 48 +/- 20 years) underwent echocardiographic examinations before any anthracycline had been administered and then after low-dose anthracycline (doxorubicin 50-125 mg/m2). The Tei index was used to compare the relative effects on RV and LV function. RESULTS: Anthracycline administration was significantly associated with an increase in the LV Tei index (0.38 +/- 0.12 vs 0.46 +/- 0.16, P = .02). There was no significant change in the RV Tei index (0.19 +/- 0.10 vs 0.20 +/- 0.10, P = .72). Comparing the relative effect on global LV and RV function the change in LV Tei was significantly greater than the change in RV Tei (0.07 +/- 0.13 vs 0.01 +/- 0.09, P = .044). CONCLUSIONS: Low-dose anthracycline administration has a significant negative impact on LV function but does not affect RV function. |
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Authors:
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Mark Belham; Anton Kruger; Colin Pritchard |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 19 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-03 Completed Date: 2006-04-26 Revised Date: 2007-11-02 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 206-10 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Royal Cornwall Hospital, Cornwall, United Kingdom. markbelham@zoom.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anthracyclines / adverse effects* Antineoplastic Agents / adverse effects Dose-Response Relationship, Drug Female Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Severity of Illness Index* Stroke Volume Ventricular Dysfunction, Left / chemically induced*, ultrasonography* Ventricular Dysfunction, Right / chemically induced*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Anthracyclines; 0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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