Document Detail

Tei index: the earliest detectable cardiac structural and functional abnormality detectable in Hb Bart's foetal edema.
MedLine Citation:
PMID:  19233491     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Premature death and still births are common in Hb Bart's foetal edema which carries significant risk to mothers. We aimed to identify early changes in cardiac structure and function in a cohort of HB Bart's foetuses, using Doppler echocardiography. METHODS: We studied 97 HB Bart's foetuses in different gestation groups; I (20-24 weeks),..., V (37-42 weeks) and compared them with age matched controls. We measured right and left atrial diameters as well as right and left ventricular diameters. From the Doppler filling and ejection velocities of the right and left ventricles we measured Tei index in 30 foetuses and compared them with age matched normal controls. RESULTS: The four cardiac chamber dimensions were not significantly different from the respective controls (p=NS for all). The right atrial diameter was enlarged in groups II, III, IV and V (p<0.05 vs normal controls). The right ventricle was significantly dilated in group III, IV and V (p<0.05-0.01) compared with normals. The left atrium and left ventricle were enlarged in groups III and IV, respectively (p<0.05 vs normals). Transmitral and transtricuspid E/A ratio was significantly less than normal in groups III (p<0.01), IV (p<0.05) and IV (p<0.05). LV and RV fractional shortening and stroke distance of group IV and V were significantly less than the respective normals (p<0.05 for all). LV and RV Tei index increased progressively from 20-week gestation (p<0.05) with respect to controls. CONCLUSIONS: In HB Bart's foetuses left and right ventricular asynchrony develop earlier than overt cavity dilatation and impairment of systolic function. The use of such markers of ventricular asynchronous function may play an important role in optimum management of these pregnancies.
Guihua Chao; Chenguang Zheng; Dahua Meng; Jialing Su; Xijin Xie; Wei Li; Michael Henein
Publication Detail:
Type:  Comparative Study; Letter; Research Support, Non-U.S. Gov't     Date:  2009-02-23
Journal Detail:
Title:  International journal of cardiology     Volume:  134     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e150-4     Citation Subset:  IM    
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MeSH Terms
Cardiovascular Diseases / blood,  diagnosis
Cohort Studies
Early Diagnosis
Echocardiography, Doppler / methods
Fetal Heart / abnormalities*,  physiology,  ultrasonography*
Hemoglobins, Abnormal* / analysis
Hydrops Fetalis / blood*,  diagnosis*
Young Adult
Reg. No./Substance:
0/Hemoglobins, Abnormal; 9056-09-1/hemoglobin Bart's

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