Document Detail

Tei index correlates with tissue Doppler parameters and reflects neurohormonal activation in patients with an abnormal transmitral flow pattern.
MedLine Citation:
PMID:  19558518     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tei index (TI) is a Doppler parameter which reflects combined systolic and diastolic function. We aimed to study the relationship between TI, both traditional and tissue Doppler imaging (TDI) echocardiographic parameters and neurohormonal profile in outpatients with diastolic dysfunction expressed by an abnormal transmitral flow pattern. METHODS AND RESULTS: A total of 67 consecutive outpatients with diastolic dysfunction (abnormal transmitral flow pattern) were studied; all patients underwent clinical evaluation, blood sampling for B-type natriuretic peptide (BNP) plasma assaying, echocardiography for the determination of left ventricular ejection fraction (LVEF), dP/dt, left atrium (LA) dimensions, longitudinal systolic (S) and diastolic wall velocities (E'and A'), TI measured with Doppler echocardiography, and mitral regurgitation (MR) quantified on a semicontinuous scale. TI values were significantly correlated with BNP levels (r = 0.33; P < 0.01), LVEF (r =-0.56; P < 0.001), dP/dt (r =-0.52; P < 0.01), S (r =-0.45; P < 0.001), E'(r =-0.36; P < 0.01), A'(r =-0.27; P < 0.05), LA volume (r = 0.35; P < 0.01), and MR (P for trend < 0.05). In a multivariate regression analysis, TI was an independent predictor of increased BNP levels (beta= 0.32; P < 0.05), even after correction for potential confounders. ROC analysis showed as values of TI >0.59 identified subjects with combined systolic and diastolic dysfunction with a sensitivity of 73.8% and a specificity of 71.4%. CONCLUSIONS: In outpatients with diastolic dysfunction, TI, an easy to perform parameter for global ventricular performance assessment, might be useful in identifying subjects with concomitant systolic impairment and neurohormonal activation.
Stefania Greco; Federica Troisi; Natale Daniele Brunetti; Matteo Di Biase
Related Documents :
15182768 - European reference values for doppler indices of left ventricular diastolic filling.
16164578 - Left ventricular function and calcium phosphate plasma levels in uraemic patients.
18296408 - Prognostic importance of tissue doppler-derived diastolic function in patients presenti...
22353438 - Cardiac troponin i: prothrombotic risk marker in non-valvular atrial fibrillation.
8458728 - Focal headache during balloon inflation in the vertebral and basilar arteries.
11119468 - Three dimensional intravascular ultrasonic assessment of the local mechanism of resteno...
Publication Detail:
Type:  Journal Article     Date:  2009-06-17
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  26     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1012-8     Citation Subset:  IM    
Department of Cardiology, University of Foggia, Foggia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Elasticity Imaging Techniques / methods*
Mitral Valve Insufficiency / blood*,  complications,  ultrasonography*
Natriuretic Peptide, Brain / blood*
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Ventricular Dysfunction, Left / blood*,  complications,  ultrasonography*
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chronic cigarette smoking affects left and right ventricular long-axis function in healthy young sub...
Next Document:  Effect of extreme exercise on myocardial function as assessed by tissue Doppler imaging.