| Tegument proteins of human cytomegalovirus. | |
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MedLine Citation:
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PMID: 18535146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human cytomegalovirus (HCMV) is a common, medically relevant human herpesvirus. The tegument layer of herpesvirus virions lies between the genome-containing capsids and the viral envelope. Proteins within the tegument layer of herpesviruses are released into the cell upon entry when the viral envelope fuses with the cell membrane. These proteins are fully formed and active and control viral entry, gene expression, and immune evasion. Most tegument proteins accumulate to high levels during later stages of infection, when they direct the assembly and egress of progeny virions. Thus, viral tegument proteins play critical roles at the very earliest and very last steps of the HCMV lytic replication cycle. This review summarizes HCMV tegument composition and structure as well as the known and speculated functions of viral tegument proteins. Important directions for future investigation and the challenges that lie ahead are identified and discussed. |
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Authors:
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Robert F Kalejta |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Microbiology and molecular biology reviews : MMBR Volume: 72 ISSN: 1098-5557 ISO Abbreviation: Microbiol. Mol. Biol. Rev. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-06 Completed Date: 2008-07-31 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 9706653 Medline TA: Microbiol Mol Biol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 249-65, table of contents Citation Subset: IM |
Affiliation:
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Institute for Molecular Virology and McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, USA. rfkalejta@wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytomegalovirus
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genetics,
metabolism,
physiology* Cytomegalovirus Infections / virology Humans Viral Structural Proteins / genetics, metabolism* Virion / genetics, metabolism, physiology Virus Replication |
| Grant Support | |
ID/Acronym/Agency:
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1R56-AI64703-01A2/AI/NIAID NIH HHS; R01 AI074984-01A1/AI/NIAID NIH HHS; R01 AI074984-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Viral Structural Proteins |
| Comments/Corrections | |
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