Document Detail


Tegmental pedunculopontine lesions in rats decrease saccharin's rewarding effects but not its memory-improving effect.
MedLine Citation:
PMID:  7826519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tegmental pedunculopontine nucleus (TPP) of the brainstem has been identified as a critical substrate for both opiate and food reward in nondeprived rats. In this study of rats, TPP lesions blocked saccharin-conditioned place preferences, in both the presence and the absence of water deprivation. TPP lesions also attenuated the unconditioned intake of saccharin and water over several hours after recovery from food and water deprivation. TPP lesions did not block saccharin preferences over water in short-duration tests. The researchers propose that the absence of a lesion effect may reflect previously conditioned discriminations. TPP lesions had no effect on the ability of posttrial presentations of a 3.2% saccharin solution to improve lithium-chloride-conditioned taste aversions. TPP lesions dissociate 2 behavioral processes elicited by saccharin: One mediates unconditioned-reward-conditioned-reinforcing effects, and another mediates the memory-improving effect.
Authors:
T L Stefurak; D van der Kooy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  108     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  972-80     Citation Subset:  IM    
Affiliation:
Department of Anatomy, University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Association Learning / physiology
Avoidance Learning / physiology
Brain Mapping
Brain Stem / physiology*
Conditioning, Classical / physiology
Discrimination Learning / physiology
Food Preferences / physiology*
Male
Mental Recall / physiology*
Motivation*
Orientation / physiology
Rats
Rats, Wistar
Saccharin
Taste / physiology*
Tegmentum Mesencephali / physiology*
Chemical
Reg. No./Substance:
81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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