| Tegmental pedunculopontine lesions in rats decrease saccharin's rewarding effects but not its memory-improving effect. | |
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MedLine Citation:
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PMID: 7826519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tegmental pedunculopontine nucleus (TPP) of the brainstem has been identified as a critical substrate for both opiate and food reward in nondeprived rats. In this study of rats, TPP lesions blocked saccharin-conditioned place preferences, in both the presence and the absence of water deprivation. TPP lesions also attenuated the unconditioned intake of saccharin and water over several hours after recovery from food and water deprivation. TPP lesions did not block saccharin preferences over water in short-duration tests. The researchers propose that the absence of a lesion effect may reflect previously conditioned discriminations. TPP lesions had no effect on the ability of posttrial presentations of a 3.2% saccharin solution to improve lithium-chloride-conditioned taste aversions. TPP lesions dissociate 2 behavioral processes elicited by saccharin: One mediates unconditioned-reward-conditioned-reinforcing effects, and another mediates the memory-improving effect. |
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Authors:
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T L Stefurak; D van der Kooy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioral neuroscience Volume: 108 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-02-23 Completed Date: 1995-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 972-80 Citation Subset: IM |
Affiliation:
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Department of Anatomy, University of Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Association Learning / physiology Avoidance Learning / physiology Brain Mapping Brain Stem / physiology* Conditioning, Classical / physiology Discrimination Learning / physiology Food Preferences / physiology* Male Mental Recall / physiology* Motivation* Orientation / physiology Rats Rats, Wistar Saccharin Taste / physiology* Tegmentum Mesencephali / physiology* |
| Chemical | |
Reg. No./Substance:
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81-07-2/Saccharin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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