Document Detail


Tecoma sambucifolia: anti-inflammatory and antinociceptive activities, and 'in vitro' toxicity of extracts of the 'huarumo' of peruvian incas.
MedLine Citation:
PMID:  10837987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aqueous and alcoholic extracts of pods and flowers of Tecoma sambucifolia H.B.K. (Bignoniaceae) ('huarumo') were analysed to determine their anti-inflammatory activity (carrageenan-induced edema test), antinociceptive activity (acetic acid writhing test) and 'in vitro' toxicity in Chinese hamster ovary cells, human hepatome cells and human larynx epidermal carcinoma cells. The cytotoxic effects of both extracts were evaluated by two endpoint systems: neutral red uptake assay and tetrazolium assay. The results showed that all extracts have anti-inflammatory and antinociceptive activity, but the highest potency is that of the alcoholic extracts. There were significant differences in cytotoxicity between extracts and among the response of cells to them. The highest cytotoxicity was noted with the alcoholic extract, and the human hepatome cell line was the most sensitive, especially to the alcoholic extract of flowers. The aqueous pod extract appeared to have the best pharmaco-toxicological profile, since it provided a significant reduction of both pain and inflammation together with the lowest cytotoxicity.
Authors:
L F Alguacil; A Galán de Mera; J Gómez; F Llinares; L Morales; M D Muñoz-Mingarro; J M Pozuelo; J A Vicente Orellana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  70     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Affiliation:
Departamento de CC Biomédicas, Universidad San Pablo-CEU, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid
Analgesics, Non-Narcotic / isolation & purification,  pharmacology*
Animals
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification,  pharmacology*
Antineoplastic Agents, Phytogenic / pharmacology
Behavior, Animal / drug effects
CHO Cells
Carrageenan
Cricetinae
Drug Screening Assays, Antitumor
Edema / chemically induced,  prevention & control
Indians, South American
Male
Medicine, Traditional
Mice
Pain / chemically induced,  prevention & control
Peru
Plant Extracts / chemistry,  toxicity
Plants, Medicinal / chemistry*
Rats
Rats, Sprague-Dawley
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 64-19-7/Acetic Acid; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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