| Technology insight: in vivo cell tracking by use of MRI. | |
| | |
MedLine Citation:
|
PMID: 16990841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Animal studies have shown some success in the use of stem cells of diverse origins to treat heart failure and ventricular dysfunction secondary to ischemic injury. The clinical use of these cells is, therefore, promising. In order to develop effective cell therapies, the location, distribution and long-term viability of these cells must be evaluated in a noninvasive manner. MRI of cells labeled with magnetically visible contrast agents after either direct injection or local or intravenous infusion has the potential to fulfill this goal. In this Review, techniques for labeling and imaging a variety of cells will be discussed. Particular attention will be given to the advantages and limitations of various contrast agents and passive and facilitated cell-labeling methods, as well as to imaging techniques that produce negative and positive contrast, and the effect on image quantification of compartmentalization of contrast agents within the cell. |
| | |
Authors:
|
Walter J Rogers; Craig H Meyer; Christopher M Kramer |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Nature clinical practice. Cardiovascular medicine Volume: 3 ISSN: 1743-4297 ISO Abbreviation: Nat Clin Pract Cardiovasc Med Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-22 Completed Date: 2006-11-13 Revised Date: 2013-04-11 |
Medline Journal Info:
|
Nlm Unique ID: 101226507 Medline TA: Nat Clin Pract Cardiovasc Med Country: England |
Other Details:
|
Languages: eng Pagination: 554-62 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Virginia Health System, Charlottesville, VA 22908, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Differentiation Cell Proliferation Cell Survival Contrast Media / chemistry, metabolism* Dendritic Cells / metabolism Dextrans Electroporation / methods Endocytosis* Ferumoxytol Heart Diseases / therapy Humans Iron / chemistry, metabolism Macrophages / metabolism Magnetic Resonance Imaging* Magnetics Magnetite Nanoparticles Oxides / chemistry, metabolism Receptors, Cell Surface / metabolism Staining and Labeling* / methods Stem Cell Transplantation Stem Cells / cytology, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Magnetite Nanoparticles; 0/Oxides; 0/Receptors, Cell Surface; 0/ferumoxtran-10; 1317-61-9/Ferumoxytol; 7439-89-6/Iron; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Therapy insight: malignant primary cardiac tumors.
Next Document: Mechanisms of disease: erythropoietin--an old hormone with a new mission?