Document Detail


Technological advancements for the detection of and protection against biological and chemical warfare agents.
MedLine Citation:
PMID:  17325785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a growing need for technological advancements to combat agents of chemical and biological warfare, particularly in the context of the deliberate use of a chemical and/or biological warfare agent by a terrorist organization. In this tutorial review, we describe methods that have been developed both for the specific detection of biological and chemical warfare agents in a field setting, as well as potential therapeutic approaches for treating exposure to these toxic species. In particular, nerve agents are described as a typical chemical warfare agent, and the two potent biothreat agents, anthrax and botulinum neurotoxin, are used as illustrative examples of potent weapons for which countermeasures are urgently needed.
Authors:
Lisa M Eubanks; Tobin J Dickerson; Kim D Janda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-11
Journal Detail:
Title:  Chemical Society reviews     Volume:  36     ISSN:  0306-0012     ISO Abbreviation:  Chem Soc Rev     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-27     Completed Date:  2007-04-27     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0335405     Medline TA:  Chem Soc Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  458-70     Citation Subset:  IM    
Affiliation:
Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Anthrax / microbiology,  prevention & control
Bacillus anthracis / isolation & purification
Biological Warfare / prevention & control*
Botulism / microbiology,  prevention & control
Chemical Warfare / prevention & control*
Chemical Warfare Agents* / analysis,  chemistry,  poisoning
Clostridium botulinum / isolation & purification
Decontamination / methods
Molecular Structure
Poisoning / diagnosis,  prevention & control
Protective Agents / administration & dosage,  therapeutic use
Grant Support
ID/Acronym/Agency:
AI062014/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Chemical Warfare Agents; 0/Protective Agents

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