Document Detail


Techniques: species' finest blend--humanized mouse models in inflammatory skin disease research.
MedLine Citation:
PMID:  15380939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differences between humans and mice often hamper the transfer of promising results from the bench to the clinic. For ethical reasons, research that involves patients is limited, and so there is an urgent need for models that mimic the human situation as closely as possible. In recent years, there has been considerable progress in generating humanized mouse models, and their application to drug discovery has proved fruitful. So, how can mice be humanized, and how can humanized mice be employed in immunology research and drug discovery? In this article, we answer these questions, focusing on T-cell-mediated skin diseases as an example.
Authors:
Frederik H Igney; Khusru Asadullah; Thomas M Zollner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  25     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-21     Completed Date:  2004-11-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  543-9     Citation Subset:  IM    
Affiliation:
Schering AG, CRBA Dermatology, Berlin, Germany. frederik.igney@schering.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Dermatitis / drug therapy*,  immunology*
Disease Models, Animal*
Humans
Mice / immunology*
Research Design*
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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