Document Detail


Techniques for evaluation of right ventricular relaxation rate in horses and effects of inhalant anesthetics with and without intravenous administration of calcium gluconate.
MedLine Citation:
PMID:  10407482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the most repeatable method for evaluating right ventricular relaxation rate in horses and to determine and compare effects of isoflurane or halothane with and without the added influence of intravenously administered calcium gluconate on right ventricular relaxation rates in horses. ANIMALS: 6 Thoroughbred horses from 2 to 4 years old. PROCEDURE: 6 models (2 for monoexponential decay with zero asymptote, 3 for monoexponential decay with variable asymptote, and 1 for biexponential decay) for determining right ventricular relaxation rate were assessed in conscious and anesthetized horses. The 2 methods yielding the most repeatable results then were used to determine right ventricular relaxation rates in horses anesthetized with isoflurane or halothane before, during, and after i.v. administration of calcium gluconate. Right ventricular pressure was measured, using a catheter-tip high-fidelity pressure transducer, and results were digitized at 500 Hz from minimum rate of change in ventricular pressure. RESULTS: 2 models that used monoexponential decay with zero asymptote repeatedly produced an estimate for relaxation rate and were used to analyze effects of anesthesia and calcium gluconate administration on relaxation rate. Isoflurane and halothane each prolonged right ventricular relaxation rate, with greater prolongation evident in halothane-anesthetized horses. Calcium gluconate attenuated the anesthesia-induced prolongation in right ventricular relaxation rate, with greater response obtained in isoflurane-anesthetized horses. CONCLUSIONS AND CLINICAL RELEVANCE: Right ventricular relaxation rate in horses is assessed best by use of a monoexponential decay model with zero asymptote and nonlinear regression. Intravenous administration of calcium gluconate to isoflurane-anesthetized horses best preserves myocardial relaxant function.
Authors:
T L Grubb; P D Constable; G J Benson; J H Foreman; W O Olson; J C Thurmon; W J Tranquilli; L E Davis
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  60     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-02     Completed Date:  1999-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  872-9     Citation Subset:  IM    
Affiliation:
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / therapeutic use*
Animals
Calcium Gluconate / therapeutic use
Female
Halothane / therapeutic use
Heart Function Tests / veterinary*
Heart Ventricles / physiopathology*
Horse Diseases / diagnosis,  physiopathology*
Horses
Injections, Intravenous / veterinary
Isoflurane / therapeutic use
Male
Models, Biological*
Regression Analysis
Reproducibility of Results
Xylazine / therapeutic use
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 151-67-7/Halothane; 26675-46-7/Isoflurane; 299-28-5/Calcium Gluconate; 7361-61-7/Xylazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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