Document Detail

Technique for routine use of heparin bonded circuits with a reduced anticoagulation protocol.
MedLine Citation:
PMID:  11194057     Owner:  NLM     Status:  MEDLINE    
The use of heparin-bonded cardiopulmonary bypass circuits (HBCs) with reduced anticoagulation protocol during cardiac surgery attenuates some of the adverse pathophysiologic responses to cardiopulmonary bypass (CPB). The strategies of how to maximize improvements in clinical outcomes using this technique are still debated. This article describes in detail a comprehensive approach to strategies developed at Boston Medical Center and the West Roxbury Veteran Affairs Medical Center in over 4000 cases in which HBC with a reduced anticoagulation protocol is used routinely. Important elements of this technique include elimination of cardiotomy reservoir during coronary artery bypass graft surgery (CABG), autologous blood priming, normothermic CPB, and precise heparin and protamine titration. Adaptation and variation in this technique to specific clinical situations is also highlighted.
P J O'Gara; P R Treanor; K J Lilly; R F Crowley; D L Reardon; S F Khuri; R J Shemin; G S Aldea
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of extra-corporeal technology     Volume:  32     ISSN:  0022-1058     ISO Abbreviation:  J Extra Corpor Technol     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267637     Medline TA:  J Extra Corpor Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  T    
Department of Cardiothoracic Surgery, Boston Medical Center and West Roxbury Veteran Affairs Medical Center, Boston University School of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Cardiopulmonary Bypass / instrumentation*
Clinical Protocols*
Equipment Design
United States
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

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