Document Detail


Technique for making hollow central airway casts.
MedLine Citation:
PMID:  6885579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a method for producing rigid hollow casts of the central airways. Woods metal (melting point 70 degrees C) was poured into the airways at the trachea of an excised canine lung air-dried at a transpulmonary pressure of 30 cmH2O. The tissue was dissolved and removed, and the resulting negative cast was carefully trimmed leaving only airways with a diameter of 2 mm or greater. The cast was then electroplated with copper that provided a rigid jacket encasing the Woods metal. Heating this structure to 100 degrees C liquefied the Woods metal allowing the majority of it to flow out. Residual amounts were readily removed by a high-pressure steam hose attached to the trachea. Comparisons were made between airway diameters from in vivo radiographic bronchograms (DB) and direct measurements of the resulting trimmed Woods metal cast (DC). Linear regression analysis of these data indicated a high degree of correlation (DC = 0.98 DB + 0.03, r = 0.99). We concluded that this technique produces positive casts which provide a good representative model of the central airways.
Authors:
C J Pedersen; J W Watson; A C Jackson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  55     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchi / anatomy & histology*
Dogs
Metals
Methods
Models, Anatomic*
Models, Structural*
Grant Support
ID/Acronym/Agency:
ES-00628/ES/NIEHS NIH HHS; HL-25631/HL/NHLBI NIH HHS; HL-26606/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Metals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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