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Technical note: Comparison of 3 methods for analyzing areas under the curve for glucose and nonesterified fatty acids concentrations following epinephrine challenge in dairy cows.
MedLine Citation:
PMID:  22118098     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The objective of the study was to compare 3 methods for calculating the area under the curve (AUC) for plasma glucose and nonesterified fatty acids (NEFA) after an intravenous epinephrine (EPI) challenge in dairy cows. Cows were assigned to 1 of 6 dietary niacin treatments in a completely randomized 6×6 Latin square with an extra period to measure carryover effects. Periods consisted of a 7-d (d 1 to 7) adaptation period followed by a 7-d (d 8 to 14) measurement period. On d 12, cows received an i.v. infusion of EPI (1.4μg/kg of BW). Blood was sampled at -45, -30, -20, -10, and -5min before EPI infusion and 2.5, 5, 10, 15, 20, 30, 45, 60, 90, and 120min after. The AUC was calculated by incremental area, positive incremental area, and total area using the trapezoidal rule. The 3 methods resulted in different statistical inferences. When comparing the 3 methods for NEFA and glucose response, no significant differences among treatments and no interactions between treatment and AUC method were observed. For glucose and NEFA response, the method was statistically significant. Our results suggest that the positive incremental method and the total area method gave similar results and interpretation but differed from the incremental area method. Furthermore, the 3 methods evaluated can lead to different results and statistical inferences for glucose and NEFA AUC after an EPI challenge.
Authors:
F C Cardoso; W Sears; S J Leblanc; J K Drackley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dairy science     Volume:  94     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6111-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Animal Sciences, University of Illinois, Urbana 61801.
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