Document Detail

Technical and methodologic considerations for performance of indirect calorimetry in ventilated and nonventilated preterm infants.
MedLine Citation:
PMID:  8989195     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate and refine indirect calorimetry measurement techniques so that accurate metabolic measurements can be performed in mechanically ventilated and convalescing preterm infants who require supplemental oxygen. DESIGN: Laboratory validation of an indirect calorimeter; clinical and laboratory assessments of technical problems in performing metabolic measurements; and clinical indirect calorimetry studies in mechanically ventilated and nonventilated preterm infants. SETTING: Neonatal intensive care unit (ICU) in a tertiary care university hospital. PATIENTS: Level II and level III mechanically ventilated (n = 10) and nonventilated (n = 14) neonatal ICU patients who required FIO2 levels ranging from 0.21 to 0.42. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: System calibration was assessed by combustion of 100% ethanol; the mean respiratory quotient was 0.667 +/- 0.001 (SEM). In addition, oxygen consumption (Vo2) and CO2 production (Vco2) were simulated by CO2/nitrogen infusions within the range expected for 0.5- to 7-kg infants. Mean relative errors were 0.6 +/- 0.3% and 1.8 +/- 0.3% for expected Vo2 and Vco2 values, respectively. In 27 mechanically ventilated patients with no audible endotracheal tube leak, measured endotracheal tube leak ranged from 0.0% to 7.5%. Fluctuations in FIO2 during mechanical ventilation were monitored in 30-min studies, using wall-source (n = 27) or tank-source (n = 11) supplemental oxygen. Mean FIO2 variation was 0.00075 +/- 0.00013 vs. 0.00011 +/- 0.00001 using wall-source and tank-source oxygen, respectively. Some of the difficulties of obtaining accurate measurements in supplemental hood oxygen studies were overcome by using tank-source vs. wall-source oxygen and a unique hood design. CONCLUSIONS: Accurate indirect calorimetry studies can be performed in both ventilated and nonventilated infants weighing as little as 500 g, providing that sufficient attention is paid to technical and methodologic measurement details.
P J Thureen; R E Phillips; M P DeMarie; A Hoffenberg; M N Bronstein; S B Spedale; W W Hay
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  25     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-02-06     Completed Date:  1997-02-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-80     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA.
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MeSH Terms
Calorimetry, Indirect / methods*,  standards
Critical Care / methods
Evaluation Studies as Topic
Infant, Newborn
Infant, Premature / metabolism*,  physiology
Infant, Very Low Birth Weight / metabolism*,  physiology
Intensive Care Units, Neonatal
Oxygen Inhalation Therapy*
Reproducibility of Results
Respiration, Artificial*
Respiratory Function Tests
Ventilators, Mechanical
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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