Document Detail


Technical aspects of fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia.
MedLine Citation:
PMID:  21238635     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In isolated congenital diaphragmatic hernia, prenatal prediction is made based on measurements of lung size and the presence of liver herniation into the thorax. A subset of fetuses likely to die in the postnatal period is eligible for fetal intervention that can promote lung growth. Rather than anatomical repair, this is now attempted by temporary fetal endoscopic tracheal occlusion (FETO). Herein we describe purpose-designed instruments that were developed thanks to a grant from the European Commission. The feasibility and safety of FETO have now been demonstrated in several active fetal surgery programs. The most frequent complication of the procedure is preterm premature rupture of the membranes, which is probably iatrogenic in nature. It does have an impact on gestational age at delivery and complicates balloon removal. FETO is associated with an apparent increase in survival compared with same severity controls, although this needs to be evaluated in a formal trial. The time has come to do so.
Authors:
Jan Deprest; Kypros Nicolaides; Elisa Done'; Paul Lewi; Gerard Barki; Eric Largen; Philip Dekoninck; Inga Sandaite; Yves Ville; Alexandra Benachi; Jacques Jani; Ivan Amat-Roldan; Eduard Gratacos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  46     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Division of Woman and Child, University Hospital Leuven, Leuven, Belgium.
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