Document Detail

Technical achievement: transthoracic Doppler echocardiography can be used to detect LAD restenosis after coronary angioplasty.
MedLine Citation:
PMID:  11100389     Owner:  NLM     Status:  MEDLINE    
We investigated the capability of transthoracic Doppler echocardiography (TTE) to detect and quantify the severity of restenosis in the left anterior descending coronary artery (LAD) after percutaneous transluminal coronary angioplasty (PTCA). We studied 10 consecutive patients assigned for quantitative coronary angiography (qCA) due to a recurrent angina pectoris after PTCA of the LAD. The LAD was visualized by TTE, and the presence of local turbulence and an increase in the blood flow velocity was regarded to indicate coronary stenosis. To assess the severity of the stenosis, the increase of blood flow velocity was measured. Angiography showed stenoses of various degrees (27-100%) in all patients. All stenoses were detectable using TTE. Moreover, the ratio of maximal blood flow velocity at the site of stenosis to the pre-stenotic blood flow velocity (M/P-ratio) correlated significantly with the reduction of the luminal diameter of LAD (r = 0.85, P < 0.003). A M/P-ratio higher than 3.0 predicted a diameter reduction of 50% or higher with sensitivity and specificity of 100% in patients with a subtotal stenosis (n = 9). Our results indicate that stenoses in the LAD could be found and the severity of the stenoses could be quantified reliably with TTE. This approach is totally non-invasive and less expensive than coronary angiography and can be used clinically in clarifying restenosis after coronary angioplasty.
M Saraste; J W Koskenvuo; J Mikkola; L Pelttari; J O Toikka; J J Hartiala
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  20     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  428-33     Citation Subset:  IM    
Department of Clinical Physiology, Turku University Central Hospital, Finland.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Blood Flow Velocity
Coronary Circulation*
Coronary Disease / therapy*,  ultrasonography*
Echocardiography, Doppler / methods*
Middle Aged
Postoperative Complications / ultrasonography
Sensitivity and Specificity

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