Document Detail

Technetium stannous pyrophosphate myocardial scintigrams in patients with chest pain of varying etiology.
MedLine Citation:
PMID:  165909     Owner:  NLM     Status:  MEDLINE    
Technetium-99m stannous pyrophosphate was utilized for myocardial imaging in 202 patients admitted to the hospital with chest pain of uncertain etiology. One hundred and one patients had clinical and evolved electrocardiographic and enzymatic evidence of acute myocardial infarction. Ninety-six of these 101 patients had increased myocardial uptake of the technetium stannous pyrophosphate and positive myocardial scintigrams; there was nearly precise correlation between the ECG and myocardial imaging localization of the area of infarction for acute transmural myocardial infarctions. In the five patients with negative myocardial images the scintigrams were obtained after seven or more days had elapsed following the myocardial infarction. In the remaining 101 patients no clinical, ECG, or enzymatic evidence of infarction developed; 92 of these patients had negative myocardial scintigrams. Seven of the remaining nine patients were admitted with "unstable angina pectoris", and despite the absence of diagnostic ECG and enzyme evolution each of these patients had faintly and diffusely positive myocardial scintigrams. The remaining two patients had positive myocardial scintigrams but no definite ECG or enzymatic evidence of acute myocardial infarction. Thus the technetium pyrophosphate imaging technique appears safe, inexpensive and to correlate well with ECG and enzyme identification of the presence of infarction and with ECG localization of myocardial infarction. In addition the positive myocardial scintigrams in some patients with "unstable angina" suggest that there may be limited myocardial necrosis that is ordinarily undetected by ECG and enzymes in these patients. The incidence of false positive and false negative scintigrams appears to be small.
J T Willerson; R W Parkey; F J Bonte; S L Meyer; J M Atkins; E M Stokley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  51     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-08-22     Completed Date:  1975-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1046-52     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / etiology
Clinical Enzyme Tests
Collateral Circulation
Diagnosis, Computer-Assisted
Diagnostic Errors
Diphosphates / administration & dosage,  diagnostic use
Evaluation Studies as Topic
Injections, Intravenous
Myocardial Infarction / diagnosis*
Radionuclide Imaging / methods*
Technetium / administration & dosage,  diagnostic use*
Reg. No./Substance:
0/Diphosphates; 7440-26-8/Technetium; 7440-31-5/Tin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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