Document Detail

Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty.
MedLine Citation:
PMID:  8708760     Owner:  NLM     Status:  MEDLINE    
This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. METHODS: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. RESULTS: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78%, 50-65% and 75-74% for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73% (qualitative analysis), 53-60% (semiquantitative analysis), 80-67% (quantitative analysis); LCX territory 83-100% (qualitative analysis); and 33-100% (semiquantitative analysis), 67-100% (quantitative analysis); and RCA territory 67-80% (qualitative analysis), 67-60% (semiquantitative analysis), 67-80% (quantitative analysis). CONCLUSION: These data suggest that 99mTc-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.
E Milan; O Zoccarato; A Terzi; F Ettori; O Leonzi; L Niccoli; R Giubbini
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  37     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-09-11     Completed Date:  1996-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1300-5     Citation Subset:  IM    
Nuclear Medicine and Cardiology Departments, Civic Hospital and University of Brescia, Italy.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Case-Control Studies
Coronary Angiography
Coronary Disease / diagnosis,  radionuclide imaging*,  therapy*
Evaluation Studies as Topic
Exercise Test
Image Processing, Computer-Assisted
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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