Document Detail


Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.
MedLine Citation:
PMID:  17449246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.
Authors:
Bao Teng; Yunpeng Bai; Yu Chang; Shizhen Chen; Zhaolong Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-30
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  17     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  3440-4     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
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MeSH Terms
Descriptor/Qualifier:
Chelating Agents / chemistry
Edetic Acid / analogs & derivatives,  chemistry
Glycine / analogs & derivatives,  chemistry
Isotope Labeling
Ligands
Magnetic Resonance Imaging / methods*
Models, Chemical
Neoplasms / diagnosis*
Radiopharmaceuticals / chemical synthesis,  diagnostic use*
Technetium / chemistry*
Thymidine / analogs & derivatives,  chemical synthesis,  diagnostic use*
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Ligands; 0/Radiopharmaceuticals; 50-89-5/Thymidine; 56-40-6/Glycine; 5657-17-0/EDDA; 5704-04-1/tricine; 60-00-4/Edetic Acid; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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