| Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging. | |
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MedLine Citation:
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PMID: 17449246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied. |
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Authors:
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Bao Teng; Yunpeng Bai; Yu Chang; Shizhen Chen; Zhaolong Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-30 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 17 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-04 Completed Date: 2007-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 3440-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Tsinghua University, Beijing 100084, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chelating Agents
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chemistry Edetic Acid / analogs & derivatives, chemistry Glycine / analogs & derivatives, chemistry Isotope Labeling Ligands Magnetic Resonance Imaging / methods* Models, Chemical Neoplasms / diagnosis* Radiopharmaceuticals / chemical synthesis, diagnostic use* Technetium / chemistry* Thymidine / analogs & derivatives, chemical synthesis, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Ligands; 0/Radiopharmaceuticals; 50-89-5/Thymidine; 56-40-6/Glycine; 5657-17-0/EDDA; 5704-04-1/tricine; 60-00-4/Edetic Acid; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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