Document Detail


Technetium-99m hexamethylpropylene amine oxime labelled leucocyte scintigraphy in ulcerative colitis and Crohn's disease.
MedLine Citation:
PMID:  8223770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Technetium-99m hexamethylpropylene amine oxime labelled leucocyte scintigraphy (LS) was performed on 45 occasions in 30 patients with ulcerative colitis and on 53 occasions in 34 patients with Crohn's disease. Serial images were taken following re-injection of the labelled leucocytes. The segmental extent of the inflammation and the grade of the leucocyte uptake were calculated, and compared with the laboratory results and colonoscopy findings. The sensitivity and specificity of LS proved higher in ulcerative colitis (87% and 93%) than in Crohn's disease (53% and 89% in cases with large intestine involvement, and 82% and 100% in cases with small intestine involvement). The activity of the process determined by LS correlates with the alpha 2-globulin level (r = 0.47), fibrinogen level (r = 0.50), fS iron level (r = -0.57), sedimentation (r = 0.44), leucocyte count (r = 0.38), platelet count (r = 0.34) and Best index (r = 0.31) in ulcerative colitis, but not in Crohn's disease.
Authors:
M Papós; F Nagy; J Láng; L Csernay
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  20     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-16     Completed Date:  1993-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  766-9     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Colitis, Ulcerative / radionuclide imaging*
Crohn Disease / radionuclide imaging*
Female
Humans
Leukocytes*
Male
Middle Aged
Organotechnetium Compounds / diagnostic use*
Oximes / diagnostic use*
Technetium Tc 99m Exametazime
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime

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