| Technetium-99m MIBI single photon emission computed tomography as an indicator of prognosis for patients with lung cancer-preliminaly report. | |
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MedLine Citation:
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PMID: 11210093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We performed technetium-99m hexakis-2-methoxyisobutylisonitrile (Tc-99m MIBI) single photon emission computed tomography (SPECT) in 23 patients with primary lung cancer between July 1993 and March 1996. We evaluated the relationships among the uptake ratio, retention index and the prognosis after radiation therapy and/or chemotherapy. MATERIALS AND METHODS: Tc-99m MIBI SPECT was performed at 30 minutes and at 3 hours after intravenous injection of 600 MBq of Tc-99m MIBI with three gamma camera detectors (GCA-9300A/HG) on transverse SPECT images. Regions of interest were set in the area of abnormal uptake of Tc-99m MIBI and in the contralateral normal lung. The ratio of uptake in the lesion to that in the contralateral normal lung was obtained on early images (early ratio; ER) as well as delayed images (delayed ratio: DR). The retention index (RI) was calculated as follows: RI = (DR - ER)/ER x 100. The ratio was compared with survival time and prognostic factors. RESULTS: There was no correlation between ER and DR. The patients with high RI survived longer than those with low RI (median survival, 19.4 months vs. 9.4 months; p = 0.0104 by the Mantel-Cox test). CONCLUSION: These results suggest that RI is the most useful among Tc-99m MIBI indices of primary lung cancer in predicting prognosis. |
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Authors:
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T Komori; I Narabayashi; R Matsui; K Sueyoshi; T Aratani; K Utsunomiya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 14 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-02-07 Completed Date: 2001-04-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 415-20 Citation Subset: IM |
Affiliation:
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Department of Radiology, Osaka Medical College,Takatsuki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Non-Small-Cell Lung / mortality, pathology, radionuclide imaging, therapy Carcinoma, Small Cell / mortality, pathology, radionuclide imaging, therapy Female Humans Lung Neoplasms / mortality, pathology, radionuclide imaging*, therapy Male Middle Aged Prognosis Radiopharmaceuticals / diagnostic use, pharmacokinetics Survival Rate Technetium Tc 99m Sestamibi / diagnostic use*, pharmacokinetics Time Factors Tissue Distribution Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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