Document Detail

Technetium-99m ethyl cysteinate dimer (ECD) cerebral accumulation and symptom and sign severity during hypothyroidism.
MedLine Citation:
PMID:  20150864     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to correlate hypothyroid-related symptomatology with regional cerebral blood flow (rCBF) during hypothyroidism.
MATERIALS AND METHODS: Nine thyroidectomized patients underwent neuropsychological testing and single photon emission computed tomography (SPECT) of their brains with technetium-99m (Tc-99m) ethyl cysteinate dimer (ECD), a lipophilic cerebral blood flow radiotracer, while hypothyroid, and again following thyroid hormone replacement. Neuropsychological test scores and TSH levels while hypothyroid were correlated with rCBF in hypothyroid-affected areas of the brain.
RESULTS: Correlations were found during hypothyroidism between the noted parameters and ECD radiotracer accumulation in the following respective regions, all of which demonstrated hypothyroid-related cerebral blood flow (CBF) aberrations: TSH and left middle occipital gyrus; psychomotor performance speed and left precentral gyrus; and depression and right middle frontal gyrus, left middle frontal gyrus, right insula, and left thalamus.
CONCLUSIONS: Severity of psychomotor impairment and depression, and TSH level during hypothyroidism appeared to correlate with CBF to brain regions associated with motor activity, mood and vision, respectively; and previously shown to manifest significantly altered rCBF during hypothyroidism.
Frank V Schraml; Lori L Beason-Held
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  31     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-05-13     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  161-7     Citation Subset:  IM    
Department of Radiology, Saint Joseph's Hospital and Medical Center and The Barrow Neurologic Institute; 350 West Thomas Rd., Phoenix, Arizona, USA.
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MeSH Terms
Brain Mapping / methods
Cerebral Cortex / metabolism*,  pathology
Cystine / analogs & derivatives*,  chemistry,  diagnostic use,  pharmacokinetics
Estrogen Replacement Therapy
Hypothyroidism / diagnosis*,  drug therapy,  metabolism,  pathology
Neuropsychological Tests
Severity of Illness Index
Technetium / chemistry,  diagnostic use*,  pharmacokinetics*
Thyroxine / therapeutic use
Young Adult
Grant Support
Reg. No./Substance:
0/ethyl cysteinate dimer; 56-89-3/Cystine; 7440-26-8/Technetium; 7488-70-2/Thyroxine

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