| Technetium-99m ethyl cysteinate dimer (ECD) cerebral accumulation and symptom and sign severity during hypothyroidism. | |
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MedLine Citation:
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PMID: 20150864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to correlate hypothyroid-related symptomatology with regional cerebral blood flow (rCBF) during hypothyroidism. MATERIALS AND METHODS: Nine thyroidectomized patients underwent neuropsychological testing and single photon emission computed tomography (SPECT) of their brains with technetium-99m (Tc-99m) ethyl cysteinate dimer (ECD), a lipophilic cerebral blood flow radiotracer, while hypothyroid, and again following thyroid hormone replacement. Neuropsychological test scores and TSH levels while hypothyroid were correlated with rCBF in hypothyroid-affected areas of the brain. RESULTS: Correlations were found during hypothyroidism between the noted parameters and ECD radiotracer accumulation in the following respective regions, all of which demonstrated hypothyroid-related cerebral blood flow (CBF) aberrations: TSH and left middle occipital gyrus; psychomotor performance speed and left precentral gyrus; and depression and right middle frontal gyrus, left middle frontal gyrus, right insula, and left thalamus. CONCLUSIONS: Severity of psychomotor impairment and depression, and TSH level during hypothyroidism appeared to correlate with CBF to brain regions associated with motor activity, mood and vision, respectively; and previously shown to manifest significantly altered rCBF during hypothyroidism. |
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Authors:
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Frank V Schraml; Lori L Beason-Held |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Neuro endocrinology letters Volume: 31 ISSN: 0172-780X ISO Abbreviation: Neuro Endocrinol. Lett. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-09 Completed Date: 2010-05-13 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 8008373 Medline TA: Neuro Endocrinol Lett Country: Sweden |
Other Details:
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Languages: eng Pagination: 161-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Saint Joseph's Hospital and Medical Center and The Barrow Neurologic Institute; 350 West Thomas Rd., Phoenix, Arizona, USA. fvschraml@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Mapping / methods Cerebral Cortex / metabolism*, pathology Cystine / analogs & derivatives*, chemistry, diagnostic use, pharmacokinetics Estrogen Replacement Therapy Female Humans Hypothyroidism / diagnosis*, drug therapy, metabolism, pathology Male Neuropsychological Tests Prognosis Severity of Illness Index Technetium / chemistry, diagnostic use*, pharmacokinetics* Thyroxine / therapeutic use Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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Z99 AG999999/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ethyl cysteinate dimer; 56-89-3/Cystine; 7440-26-8/Technetium; 7488-70-2/Thyroxine |
| Comments/Corrections | |
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