| Technetium-99m-ECD SPECT in antiphospholipid antibody syndrome: a drastic improvement in brain perfusion by antiplatelet therapy. | |
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MedLine Citation:
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PMID: 11734968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a case of antiphospholipid antibody syndrome (APS) with repeated transient ischemic attacks (TIAs). Magnetic resonance imaging showed multiple cerebral infarcts and ischemic changes in the cerebral white matter. Cerebral angiographies showed no abnormalities. Technetium-99m-ethyl cysteinate dimer (Tc-99m-ECD) brain SPECT showed multiple decreased perfusion areas, which were more extensive than the lesions demonstrated on MRI. After treatment with an antiplatelet agent, the patient subsequently recovered from the TIAs. Although no interval changes were observed by MRI after therapy, follow-up Tc-99m-ECD SPECT revealed a marked improvement in brain perfusion. This is the first imaging report of remarkable post-therapy improvement in brain perfusion in APS cases. |
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Authors:
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S Tokumaru; T Yoshikai; A Uchino; M Matsui; Y Kuroda; S Kudo |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2001-03-15 |
Journal Detail:
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Title: European radiology Volume: 11 ISSN: 0938-7994 ISO Abbreviation: Eur Radiol Publication Date: 2001 |
Date Detail:
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Created Date: 2001-12-05 Completed Date: 2002-01-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2611-5 Citation Subset: IM |
Affiliation:
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Department of Radiology, Saga Medical School, Nabeshima-5-1-1, Saga 849-8501, Japan. tokumaru@posc.saga-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiphospholipid Syndrome
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drug therapy,
radionuclide imaging* Aspirin / administration & dosage* Cerebral Infarction / drug therapy, radionuclide imaging* Cysteine / analogs & derivatives*, diagnostic use* Female Follow-Up Studies Humans Middle Aged Organotechnetium Compounds / diagnostic use* Tomography, Emission-Computed, Single-Photon* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/technetium Tc 99m bicisate; 50-78-2/Aspirin; 52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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