| Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells. | |
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MedLine Citation:
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PMID: 21362141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Tec family tyrosine kinase interleukin-2 inducible T-cell kinase (Itk) is predominantly expressed in T cells and has been shown to be critical for the development, function and differentiation of conventional αβ T cells. However, less is known about its role in nonconventional T cells such as NKT and γδ T cells. In this minireview, we discuss evidence for a role for Itk in the development of invariant NKT αβ cells, as well as a smaller population NKT-like γδ T cells. We discuss how these cells take what could be the same signaling pathway regulated by Itk, and interpret it to give different outcomes with regards to development and function. |
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Authors:
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Qian Qi; Arun Kumar Kannan; Avery August |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-03-29 |
Journal Detail:
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Title: The FEBS journal Volume: 278 ISSN: 1742-4658 ISO Abbreviation: FEBS J. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2012-02-28 Completed Date: 2012-04-30 Revised Date: 2012-06-01 |
Medline Journal Info:
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Nlm Unique ID: 101229646 Medline TA: FEBS J Country: England |
Other Details:
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Languages: eng Pagination: 1970-9 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors Journal compilation © 2011 FEBS. |
Affiliation:
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Department of Veterinary & Biomedical Sciences, Center for Molecular Immunology & Infectious Disease, The Pennsylvania State University, University Park, PA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / immunology Humans Mice Models, Immunological Natural Killer T-Cells / classification, cytology, enzymology*, immunology* Protein-Tyrosine Kinases / immunology* Receptors, Antigen, T-Cell, alpha-beta / metabolism Receptors, Antigen, T-Cell, gamma-delta / metabolism Signal Transduction / immunology T-Lymphocyte Subsets / classification, cytology, enzymology, immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI065566/AI/NIAID NIH HHS; AI073955/AI/NIAID NIH HHS; AI51626/AI/NIAID NIH HHS; R01 AI051626-11/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, T-Cell, alpha-beta; 0/Receptors, Antigen, T-Cell, gamma-delta; EC 2.7.1.-/Tec protein-tyrosine kinase; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/emt protein-tyrosine kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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