Document Detail


Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells.
MedLine Citation:
PMID:  21362141     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Tec family tyrosine kinase interleukin-2 inducible T-cell kinase (Itk) is predominantly expressed in T cells and has been shown to be critical for the development, function and differentiation of conventional αβ T cells. However, less is known about its role in nonconventional T cells such as NKT and γδ T cells. In this minireview, we discuss evidence for a role for Itk in the development of invariant NKT αβ cells, as well as a smaller population NKT-like γδ T cells. We discuss how these cells take what could be the same signaling pathway regulated by Itk, and interpret it to give different outcomes with regards to development and function.
Authors:
Qian Qi; Arun Kumar Kannan; Avery August
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-03-29
Journal Detail:
Title:  The FEBS journal     Volume:  278     ISSN:  1742-4658     ISO Abbreviation:  FEBS J.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-04-30     Revised Date:  2012-06-01    
Medline Journal Info:
Nlm Unique ID:  101229646     Medline TA:  FEBS J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1970-9     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors Journal compilation © 2011 FEBS.
Affiliation:
Department of Veterinary & Biomedical Sciences, Center for Molecular Immunology & Infectious Disease, The Pennsylvania State University, University Park, PA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / immunology
Humans
Mice
Models, Immunological
Natural Killer T-Cells / classification,  cytology,  enzymology*,  immunology*
Protein-Tyrosine Kinases / immunology*
Receptors, Antigen, T-Cell, alpha-beta / metabolism
Receptors, Antigen, T-Cell, gamma-delta / metabolism
Signal Transduction / immunology
T-Lymphocyte Subsets / classification,  cytology,  enzymology,  immunology
Grant Support
ID/Acronym/Agency:
AI065566/AI/NIAID NIH HHS; AI073955/AI/NIAID NIH HHS; AI51626/AI/NIAID NIH HHS; R01 AI051626-11/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Antigen, T-Cell, alpha-beta; 0/Receptors, Antigen, T-Cell, gamma-delta; EC 2.7.1.-/Tec protein-tyrosine kinase; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/emt protein-tyrosine kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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