| Tear Osmolarity in Premature Infants. | |
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MedLine Citation:
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PMID: 22881483 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:To measure and report tear osmolarity in premature infants and to assess the change, if any, that occurs with increasing maturity. METHODS:In a prospective study of consecutive infants born at less than 37 weeks gestational age undergoing screening for retinopathy of prematurity, serial measurements of tear osmolarity were obtained at preterm, term, and 3 months post-term. Mean ± standard deviation tear osmolarity and percentage of infants with tear osmolarity value greater than 308 and greater than 316 mOsm/L were calculated at each stage of maturity. RESULTS:Twenty-five premature infants of mean post-conceptional age 33.5 weeks and mean birth weight 1,159 ± 259 g were tested. Mean tear osmolarity was 296 ± 19.1, 302.8 ± 18, and 301.1 ± 20.9 mOsm/L at pre-term, term, and post-term, respectively. There was no significant effect for time on tear osmolarity values (P = .59). Tear osmolarity was greater than 308 mOsm/L in 32% and greater than 316 mOsm/L in 16%. CONCLUSION:Mean tear osmolarity in premature infants is within the expected normal range for adults and shows no significant change at term or post-term. More than two-thirds of premature infants have tear osmolarity values below the suggested diagnostic cut-offs for dry eye disease in adults. Most preterm infants do not have a dry eye based on assessment of tear osmolarity. |
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Authors:
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Andrea Ryan; Bernadette Lanigan; Michael O'Keefe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-07 |
Journal Detail:
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Title: Journal of pediatric ophthalmology and strabismus Volume: - ISSN: 1938-2405 ISO Abbreviation: J Pediatr Ophthalmol Strabismus Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7901143 Medline TA: J Pediatr Ophthalmol Strabismus Country: - |
Other Details:
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Languages: ENG Pagination: 1-5 Citation Subset: - |
Copyright Information:
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Copyright 2012, SLACK Incorporated. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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