Document Detail

Tear Osmolarity in Premature Infants.
MedLine Citation:
PMID:  22881483     Owner:  NLM     Status:  Publisher    
PURPOSE:To measure and report tear osmolarity in premature infants and to assess the change, if any, that occurs with increasing maturity. METHODS:In a prospective study of consecutive infants born at less than 37 weeks gestational age undergoing screening for retinopathy of prematurity, serial measurements of tear osmolarity were obtained at preterm, term, and 3 months post-term. Mean ± standard deviation tear osmolarity and percentage of infants with tear osmolarity value greater than 308 and greater than 316 mOsm/L were calculated at each stage of maturity. RESULTS:Twenty-five premature infants of mean post-conceptional age 33.5 weeks and mean birth weight 1,159 ± 259 g were tested. Mean tear osmolarity was 296 ± 19.1, 302.8 ± 18, and 301.1 ± 20.9 mOsm/L at pre-term, term, and post-term, respectively. There was no significant effect for time on tear osmolarity values (P = .59). Tear osmolarity was greater than 308 mOsm/L in 32% and greater than 316 mOsm/L in 16%. CONCLUSION:Mean tear osmolarity in premature infants is within the expected normal range for adults and shows no significant change at term or post-term. More than two-thirds of premature infants have tear osmolarity values below the suggested diagnostic cut-offs for dry eye disease in adults. Most preterm infants do not have a dry eye based on assessment of tear osmolarity.
Andrea Ryan; Bernadette Lanigan; Michael O'Keefe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-07
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  -     ISSN:  1938-2405     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Copyright Information:
Copyright 2012, SLACK Incorporated.
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