| Tea catechins as a potential alternative anti-infectious agent. | |
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MedLine Citation:
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PMID: 17547513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Besides well-known health benefits, green tea catechins exert antimicrobial and antiviral activities against a variety of infectious agents. Although the detailed mechanism of the antimicrobial activity of tea catechins remains to be explored, the broad-spectrum activity of catechins may involve common target(s), such as the cell membrane, in addition to specific targets for each pathogen. This extends to antiviral activities, where many pronounced activities were reported for enveloped viruses. Yet, the effectiveness of tea catechins as antimicrobials is compromised by relative chemical instability and poor bioavailability. Whether tea catechins will emerge as a viable option as alternative medicine or as a synergistic combination therapy with pre-existing antivirals or antibiotics must therefore depend on a method of delivery that ensures its stability and bioavailability. However, green tea may provide an option for mitigating the health and economic burdens associated with emerging and re-emerging infectious diseases, especially considering the paucity of effective control measures. Considering the zoonotic nature of newly arising infectious diseases, the dual use of green tea components in both humans and livestock may reduce animal-human transmission, which would complement the current management of infectious diseases. |
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Authors:
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Jae Min Song; Baik Lin Seong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert review of anti-infective therapy Volume: 5 ISSN: 1744-8336 ISO Abbreviation: Expert Rev Anti Infect Ther Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-05 Completed Date: 2007-07-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101181284 Medline TA: Expert Rev Anti Infect Ther Country: England |
Other Details:
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Languages: eng Pagination: 497-506 Citation Subset: IM |
Affiliation:
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Yonsei University, Department of Biotechnology, College of Engineering, 134 Shinchon-dong, Seodaemun-gu, Seoul, Korea. jaemin@yonsei.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents / chemistry, pharmacology, therapeutic use* Catechin / chemistry, pharmacology, therapeutic use* Communicable Disease Control / methods HIV / drug effects Helicobacter pylori / drug effects Herpesvirus 4, Human / drug effects Humans Microbial Sensitivity Tests Orthomyxoviridae / drug effects Phytotherapy* Staphylococcus aureus / drug effects Streptococcus mutans / drug effects Tea / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Tea; 154-23-4/Catechin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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