Document Detail


Tbr2 is required to generate a neural circuit mediating the pupillary light reflex.
MedLine Citation:
PMID:  24741035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are ∼20 types of retinal ganglion cells (RGCs) in mice, each of which has distinct molecular, morphological, and physiological characteristics. Each RGC type sends axon projections to specific brain areas that execute light-dependent behaviors. Here, we show that the T-box transcription factor Tbr2 is required for the development of several RGC types that participate in non-image-forming circuits. These types are molecularly distinct, project to non-image-forming targets, and include intrinsically photosensitive RGCs. Tbr2 mutant mice have reduced retinal projections to non-image-forming nuclei and an attenuated pupillary light reflex. These data demonstrate that Tbr2 acts to execute RGC type choice and/or survival in a set of RGCs that mediates light-induced subconscious behaviors.
Authors:
Neal T Sweeney; Hannah Tierney; David A Feldheim
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  34     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-17     Completed Date:  2014-06-06     Revised Date:  2014-10-16    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5447-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Axons / physiology*
Cadherins / genetics
Calbindin 2 / genetics,  metabolism
Female
Gene Expression Regulation / physiology*
Green Fluorescent Proteins / genetics,  metabolism
Male
Mice
Mice, Transgenic
Mutation / genetics
Pupil / physiology*
Receptors, Dopamine D4 / genetics,  metabolism
Reflex / genetics,  physiology*
Retinal Ganglion Cells / cytology,  physiology
T-Box Domain Proteins / genetics,  metabolism*
Visual Pathways / physiology*
Grant Support
ID/Acronym/Agency:
R01 EY022117/EY/NEI NIH HHS; R01EY022117/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Cadherins; 0/Calb2 protein, mouse; 0/Calbindin 2; 0/Drd4 protein, mouse; 0/Eomes protein, mouse; 0/T-Box Domain Proteins; 137750-34-6/Receptors, Dopamine D4; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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