Document Detail


Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study.
MedLine Citation:
PMID:  16475496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous investigations have reported the efficacy of tazarotene 0.1% cream for the treatment of dyschromia associated with photoaging and for acne vulgaris. The present investigation assessed tazarotene 0.1% cream for the treatment of postinflammatory hyperpigmentation (PIH) in a double-blind, randomized, vehicle-controlled study of 74 patients from darker racial ethnic groups who had acne. Once-daily application of tazarotene cream was shown to be effective against PIH, achieving significantly greater reductions compared with vehicle in overall disease severity and in the intensity and area of hyperpigmentation within 18 weeks (P< or =.05). Mean levels of erythema, burning, and peeling were no more than trace in both groups throughout the study, and mean levels of dryness were no more than mild in both groups. In our study, tazarotene cream was effective and well tolerated in the treatment of PIH in patients with darker skin.
Authors:
Pearl Grimes; Valerie Callender
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cutis     Volume:  77     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-14     Completed Date:  2006-05-25     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
Affiliation:
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA. pegrimesmd@earthlink.net
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / complications,  drug therapy*
Administration, Cutaneous
Adolescent
Adult
Aged
Aged, 80 and over
Child
Dermatologic Agents / adverse effects,  therapeutic use*
Double-Blind Method
Female
Humans
Hyperpigmentation / drug therapy*,  etiology
Male
Middle Aged
Nicotinic Acids / adverse effects,  therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Dermatologic Agents; 0/Nicotinic Acids; 118292-40-3/tazarotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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