| Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study. | |
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MedLine Citation:
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PMID: 16475496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous investigations have reported the efficacy of tazarotene 0.1% cream for the treatment of dyschromia associated with photoaging and for acne vulgaris. The present investigation assessed tazarotene 0.1% cream for the treatment of postinflammatory hyperpigmentation (PIH) in a double-blind, randomized, vehicle-controlled study of 74 patients from darker racial ethnic groups who had acne. Once-daily application of tazarotene cream was shown to be effective against PIH, achieving significantly greater reductions compared with vehicle in overall disease severity and in the intensity and area of hyperpigmentation within 18 weeks (P< or =.05). Mean levels of erythema, burning, and peeling were no more than trace in both groups throughout the study, and mean levels of dryness were no more than mild in both groups. In our study, tazarotene cream was effective and well tolerated in the treatment of PIH in patients with darker skin. |
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Authors:
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Pearl Grimes; Valerie Callender |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cutis; cutaneous medicine for the practitioner Volume: 77 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-14 Completed Date: 2006-05-25 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006440 Medline TA: Cutis Country: United States |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Affiliation:
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Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA. pegrimesmd@earthlink.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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complications,
drug therapy* Administration, Cutaneous Adolescent Adult Aged Aged, 80 and over Child Dermatologic Agents / adverse effects, therapeutic use* Double-Blind Method Female Humans Hyperpigmentation / drug therapy*, etiology Male Middle Aged Nicotinic Acids / adverse effects, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Nicotinic Acids; 118292-40-3/tazarotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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