| Tauroursodeoxycholic acid for the treatment of HCV-related chronic hepatitis: a multicenter placebo-controlled study. | |
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MedLine Citation:
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PMID: 9840118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Tauroursodeoxycholic acid is a promising drug for the treatment of chronic cholestatic liver diseases since it has more favourable physicochemical and metabolic properties than ursodeoxycholic acid. Tauroursodeoxycholic acid may be of benefit also for necroinflammatory liver disease, especially for HCV-related chronic hepatitis in which bile duct damage and some degree of cholestasis are frequently seen at histology. METHODOLOGY: One hundred and fifty patients with chronic hepatitis were randomly assigned to receive tauroursodeoxycholic acid at daily doses of 500 mg or 750 mg, or a placebo for 6 months. RESULTS: A consistent decrease in aminotransferase serum levels was observed in patients treated with tauroursodeoxycholic acid compared with placebo (p<0.001) and a progressive improvement with time was also found (p<0.05; linear time effect). CONCLUSIONS: Tauroursodeoxycholic acid improves the biochemical expression of chronic hepatitis. Long-term studies with clinically relevant end-points are warranted. |
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Authors:
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A Crosignani; G Budillon; L Cimino; C Del Vecchio Blanco; C Loguercio; G Ideo; G Raimondo; R Stabilini; M Podda |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 45 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 1998 Sep-Oct |
Date Detail:
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Created Date: 1999-02-10 Completed Date: 1999-02-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: GREECE |
Other Details:
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Languages: eng Pagination: 1624-9 Citation Subset: IM |
Affiliation:
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Division of Internal Medicine, School of Medicine San Paolo, Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Aspartate Aminotransferases / blood Clinical Enzyme Tests Double-Blind Method Female Hepatitis C, Chronic / diagnosis, drug therapy* Humans Male Middle Aged Taurochenodeoxycholic Acid / therapeutic use* gamma-Glutamyltransferase / blood |
| Chemical | |
Reg. No./Substance:
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14605-22-2/tauroursodeoxycholic acid; 516-35-8/Taurochenodeoxycholic Acid; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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