Document Detail


Tauroursodeoxycholic acid is less damaging than taurochenodeoxycholic acid to the gastric and esophageal mucosa.
MedLine Citation:
PMID:  6831999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bile acids are capable of disrupting the gastric and esophageal mucosal barriers and are known to differ in their ability to injure these mucosae. Two bile acids, chenodeoxycholic and its 7-B epimer, ursodeoxycholic, that are being used to dissolve gallbladder stones were evaluated for their damaging effects on experimental preparations of the esophageal (rabbit) and gastric (dog) mucosa. Damage was assessed by measuring indices of mucosal barrier function, including net acid flux, potential difference, and tissue resistance, before and after exposure to the taurine conjugates of these bile acids. In both the esophageal and gastric mucosa, tauroursodeoxycholic acid caused significantly less disruption of barrier function than taurochenodeoxycholic acid. These results demonstrate that minor differences in conjugated bile acid structure can cause major changes in the effects of bile acids on the upper gastrointestinal mucosa and that ursodeoxycholic acid may be the preferred bile acid for oral ingestion to dissolve gallbladder stones.
Authors:
K D Lillemoe; G W Kidder; J W Harmon; T R Gadacz; L F Johnson; R M Bunte; A F Hofmann
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  28     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-64     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / therapeutic use
Chenodeoxycholic Acid / analogs & derivatives*
Cholelithiasis / drug therapy
Dogs
Esophagus / drug effects*
Gastric Mucosa / drug effects*
Mucous Membrane / drug effects
Rabbits
Taurochenodeoxycholic Acid / pharmacology*
Grant Support
ID/Acronym/Agency:
AM 21506/AM/NIADDK NIH HHS; AM-21835-02/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 14605-22-2/tauroursodeoxycholic acid; 474-25-9/Chenodeoxycholic Acid; 516-35-8/Taurochenodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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