Document Detail


Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate.
MedLine Citation:
PMID:  7615207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: To explain the greater hepatoprotective effect of tauroursodeoxycholic acid vs. ursodeoxycholic acid, the absorption, hepatic enrichment, and biotransformation of these bile acids (250 mg/day) were compared in rats. METHODS: Bile acids were determined in intestinal contents, feces, urine, plasma, and liver by gas chromatography-mass spectrometry. RESULTS: The concentration of ursodeoxycholate in the liver of animals administered tauroursodeoxycholic acid (175 +/- 29 nmol/g) was greater (P < 0.05) than in animals administered ursodeoxycholic acid (79 +/- 19 nmol/g). Hepatic lithocholate was substantially higher after ursodeoxycholic acid administration (21 +/- 10 nmol/g) than after tauroursodeoxycholic acid administration (12 +/- 1 nmol/g). A concomitant reduction in the proportion of hydrophobic bile acids occurred that was greatest during tauroursodeoxycholic acid administration. In the intestinal tract, the mass of ursodeoxycholate and its specific metabolites was greater in rats administered tauroursodeoxycholic acid (27.2 mg) than those administered ursodeoxycholic acid (13.2 mg). In feces, the proportion of lithocholate was 21.9% +/- 4.9% and 5.4% +/- 4.0% after ursodeoxycholic acid and tauroursodeoxycholic acid administration, respectively. CONCLUSIONS: Compared with ursodeoxycholic acid, tauroursodeoxycholic acid induces a greater decrease in the percent composition of more hydrophobic bile acids within the pool, limits lithocholate formation, and increases hepatic ursodeoxycholate concentration. These differences are explained by increased hepatic extraction and reduced intestinal biotransformation and not by enhanced absorption of the amidated species.
Authors:
C M Rodrigues; B T Kren; C J Steer; K D Setchell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  109     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  564-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Biotransformation
Feces / chemistry
Gas Chromatography-Mass Spectrometry
Intestines / chemistry
Lithocholic Acid / biosynthesis*
Liver / chemistry,  metabolism*
Male
Plasma / chemistry
Rats
Rats, Sprague-Dawley
Taurochenodeoxycholic Acid / analysis,  metabolism*
Urine / chemistry
Ursodeoxycholic Acid / analysis,  metabolism*
Chemical
Reg. No./Substance:
128-13-2/Ursodeoxycholic Acid; 14605-22-2/tauroursodeoxycholic acid; 434-13-9/Lithocholic Acid; 516-35-8/Taurochenodeoxycholic Acid

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