Document Detail

Taurocholate pool size and distribution in the fetal rat.
MedLine Citation:
PMID:  447826     Owner:  NLM     Status:  MEDLINE    
Taurocholate concentrations in fetal and neonatal rats were determined by radioimmunoassay. Total body taurocholate pool size varied from 0.0049 +/- 0.0008 to 203 +/- 8 nmol/g body weight from day 5 of gestation to 5 d after birth. A 50-fold increase in taurocholate pool size was observed between days 15 and 19 of gestation. The distribution of taurocholate between liver, intestine, and the remainder of the carcass was determined for rats of gestational age 19 d to 5 d after birth. The major fraction of total body taurocholate was in the liver and intestine, with less than 15% in the remainder of the carcass. The ratio of taurocholate in intestine to taurocholate in liver, which was 1:17 at 19 d of gestation, had altered substantially to a ratio of 6:1 by 5 d after birth. Treatment of pregnant rats with 60 microgram/d of dexamethasone from gestational day 9 until sacrifice increased fetal taurocholate pool size by 80% at 15 d, 40% at 19 d, and 16% at 1 d after birth. Administration of dexamethasone to the mother also changed the ratio of taurocholate in intestine to taurocholate in liver. At 19 d of gestation, dexamethasone-treated mothers had fetuses with approximately equal amounts of taurocholate in intestine and liver. This suggested that adrenocorticosteroids stimulate the early maturation of factors controlling taurocholate pool size and tissue distribution in the rat fetus.
J M Little; J E Richey; D H Van Thiel; R Lester
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  63     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-08-16     Completed Date:  1979-08-16     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1042-9     Citation Subset:  AIM; IM    
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MeSH Terms
Animals, Newborn / metabolism
Cholic Acids / metabolism
Dexamethasone / pharmacology
Fetus / drug effects,  metabolism*
Intestines / metabolism
Liver / metabolism
Phenobarbital / pharmacology
Taurocholic Acid / metabolism*
Reg. No./Substance:
0/Cholic Acids; 50-02-2/Dexamethasone; 50-06-6/Phenobarbital; 81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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