| Taurine: a potential novel addition to the anti-systemic sclerosis weaponry. | |
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MedLine Citation:
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PMID: 20430256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular damage and immunological events leading to generation of fibrogenic fibroblasts are the main components of systemic sclerosis (SSc) pathogenesis. Superoxide anions play a role in endothelial damage by oxidizing circulating low-density lipoproteins. IL-1 plays a key role in the pathophysiology of SSc by inducing upregulation of adhesion molecules, inflammatory damage of the endothelium and tissue fibrosis. Elevated levels of proTh2 cytokines such as IL-6 in the early stages of SSc lead to enhanced fibroblast collagen production. Taurine, a semi-essential amino acid, is an antioxidant, inhibits the production of proinflammatory cytokines such as IL-1 and IL-6 and also inhibits production of TGF-beta, a major fibrogenic cytokine. Therefore, we conclude that taurine may be a novel addition to the treatment armamentarium of this disabling disorder. |
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Authors:
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Mohammad Kazem Fallahzadeh; Mohammad Reza Namazi; Ramesh C Gupta |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-29 |
Journal Detail:
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Title: Archives of medical research Volume: 41 ISSN: 1873-5487 ISO Abbreviation: Arch. Med. Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 59-61 Citation Subset: IM |
Copyright Information:
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2010 IMSS. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Shiraz Nephrourology Research Center and Dermatology Department, Shiraz University of Medical Sciences, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Scleroderma, Systemic / drug therapy*, physiopathology Taurine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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107-35-7/Taurine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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