Document Detail


Taurine inhibits ischemia/reperfusion-induced compartment syndrome in rabbits.
MedLine Citation:
PMID:  15960888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate effects of taurine on ischemia/reperfusion (I/R)-induced compartment syndrome in rabbit hind limbs. METHODS: Rabbits underwent femoral artery occlusion after ligation of branches from terminal aorta to femoral artery. After a 7-h ischemia, reperfusion was established with the use of heparinized polyethylene shunts. Rabbits received taurine (1g/kg) or normal saline (control) by iv infusion 10 min before shunt placement. During reperfusion, anterior compartment pressure (ACP) was monitored continuously in the left lower extremity. Gastrocnemius muscle triphenyltetrazolium chloride (TTC) level, taurine content and myeloperoxidase activity were assayed. Oxidative stress was induced in the in vitro gastrocnemius muscle slices by free radical generating systems (FRGS), and the malondialdehyde content was measured in presence or absence of taurine. RESULTS: After 7 h of ischemia, none of the parameters that we measured were different from those before ischemia, except that TTC reduction decreased by 80%. In the control group, after 2 h of reperfusion, ACP increased 4.5-fold, and gastrocnemius muscle taurine content was reduced by 33%. In taurine-treated animals, at 2h reperfusion, the mean arterial blood pressure and heart rate were increased, by 6% and 10%. ACP decreased by 39%, muscle edema decreased by 16%, TTC reduction increased by 150%, and lactate dehydrogenase decreased by 36% compared to control group. Plasma and muscle taurine content increased by 70% and 88%, respectively. In the taurine-treated group, at 2 h reperfusion, plasma malondialdehyde and conjugated diene content were decreased by 38% and 23%, respectively, and muscle malondialdehyde and conjugated diene content decreased by 22% and 30%, respectively compared to the control group. At 2 h reperfusion, myeloperoxidase activity was increased 3.5-fold in control animals. In the in vitro study, taurine decreased malondialdehyde content in muscle slices incubated with hypochlorous acid in a dose-dependent manner, but there was no change when incubated with hydrogen peroxide and xanthine oxidase. CONCLUSION: Treatment with taurine inhibited I/R-induced compartment syndrome by at least in part attenuating oxidative stress injury induced by I/R, suggesting clinical application of taurine might be a new strategy for the prevention and treatment of compartment syndrome.
Authors:
Ji-Xian Wang; Yan Li; Li-Ke Zhang; Jing Zhao; Yong-Zheng Pang; Chao-Shu Tang; Jing Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  26     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-17     Completed Date:  2006-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  821-7     Citation Subset:  IM    
Affiliation:
Institute of Cardiovascular Disease Research, The First Hospital of Peking University, Beijing 100034, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Compartment Syndromes / etiology,  physiopathology,  prevention & control*
L-Lactate Dehydrogenase / blood
Malondialdehyde / metabolism
Muscle, Skeletal / metabolism
Oxidative Stress / drug effects
Pressure
Rabbits
Random Allocation
Reperfusion Injury / complications*,  physiopathology
Taurine / pharmacology*
Tetrazolium Salts / metabolism
Chemical
Reg. No./Substance:
0/Tetrazolium Salts; 107-35-7/Taurine; 542-78-9/Malondialdehyde; 902-00-1/triphenyltetrazolium; EC 1.1.1.27/L-Lactate Dehydrogenase

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