Document Detail


Taurine entry into perilymph of the guinea pig.
MedLine Citation:
PMID:  9783127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Taurine is a beta-aminosulfonic acid and is a ubiquitous amino acid whose role in the cochlea is not well established. In this study, its entry from blood into perilymph was investigated in the guinea pig as animal model. The penetration rate of [3H]taurine (molecular weight 125) into the perilymph of the scala vestibuli was measured 1 and 2 h after the intravenous infusion of [3H]taurine in nephrectomized animals. Results showed a rate of penetration in perilymph related to plasma at 36 +/- 4.7% (n = 5) after 1 h and 43 +/- 5.6% (n = 5) after 2 h. Compared to the penetration rate of urea (molecular weight 60) and mannitol (molecular weight 186) reported previously in rats, a passive entry of taurine into perilymph through the blood-perilymph barrier is suggested.
Authors:
E Angelini; M Teixeira; J M Aran; E Ferrary
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  255     ISSN:  0937-4477     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-17     Completed Date:  1998-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  IM    
Affiliation:
Laboratoire d'Audiologie Expérimentale et Clinique, CJF INSERM 97-04, Université Bordeaux II, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile / chemistry
Blood Proteins / analysis
Chlorides / analysis,  blood
Disease Models, Animal
Diuretics, Osmotic / pharmacokinetics
Follow-Up Studies
Guinea Pigs
Infusions, Intravenous
Mannitol / pharmacokinetics
Nephrectomy
Osmolar Concentration
Perilymph / chemistry,  metabolism*
Potassium / analysis,  blood
Proteins / analysis
Radiopharmaceuticals / diagnostic use
Rats
Scala Tympani / metabolism
Sodium / analysis,  blood
Taurine / administration & dosage,  blood,  pharmacokinetics*
Tritium / diagnostic use
Urea / pharmacokinetics
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Chlorides; 0/Diuretics, Osmotic; 0/Proteins; 0/Radiopharmaceuticals; 10028-17-8/Tritium; 107-35-7/Taurine; 57-13-6/Urea; 69-65-8/Mannitol; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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