Document Detail

Taurine decreases fecal fatty acid and sterol excretion in cystic fibrosis. A randomized double-blind trial.
MedLine Citation:
PMID:  1669669     Owner:  NLM     Status:  MEDLINE    
Patients with cystic fibrosis may still have a significant degree of steatorrhea despite adequate pancreatic enzyme supplementation. Taurine is a conditionally essential amino acid that possibly improves the micellar phase of fat digestion. Thirteen children with cystic fibrosis and a significant degree of steatorrhea (> 13 g/d) were enrolled in a randomized double-blind crossover study of taurine (30 mg/kg per day) in contrast to placebo for two successive 4-month periods. No difference was noted in height and weight velocity, lung function, vitamin A level, and essential fatty acid status. Twelve of the 13 patients showed a decrease in fecal fatty acid excretion (26.5 +/- 2.6 g/24 h vs 15.4 +/- 2.5 g/24 h), affecting mainly saturates and monounsaturates, and a decrease in total sterol excretion (1492.6 +/- 303 mg/24 h vs 1211.7 +/- 213.8 mg/24 h) while ingesting taurine. Taurine may be a useful adjunct in patients with cystic fibrosis and severe steatorrhea.
L J Smith; F Lacaille; G Lepage; N Ronco; A Lamarre; C C Roy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  145     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1994-02-24     Completed Date:  1994-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1401-4     Citation Subset:  AIM; IM    
Department of Pediatrics, Hôpital Ste-Justine, Montréal, Québec, Canada.
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MeSH Terms
Body Height
Body Weight
Celiac Disease / blood,  drug therapy*,  etiology,  physiopathology
Cystic Fibrosis / complications*
Double-Blind Method
Fatty Acids / analysis
Feces / chemistry
Forced Expiratory Flow Rates
Nutritional Status
Sterols / analysis
Taurine / pharmacology,  therapeutic use*
Vital Capacity
Vitamin A / blood
Reg. No./Substance:
0/Fatty Acids; 0/Sterols; 107-35-7/Taurine; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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